Table 4 Distribution of combinations of rs12998782 and rs1194182, or rs12998782 and rs10499859 genotype frequencies in PTB patients and healthy controls

rs12998782

rs1194182

 CC

CC

29 (14.3%)

31 (14.4%)

Reference

Reference

 CT

CC

14 (6.9%)

16 (7.4%)

0.956

0.022

0.532–1.718

0.881

 TT

CC

2 (1.0%)

4 (1.9%)

0.565

0.075

0.111–2.873

0.785

 CC

CG

70(34.7%)

60(27.8%)

1.072

0.5

0.883–1.303

0.48

 CT

CG

43(21.3%)

37(17.1%)

1.098

0.403

0.882–1.456

0.526

 TT

CG

13 (6.4%)

2 (0.9%)

5.107

7.156

1.238–21.069

0.007*

 CC

GG

18 (8.9%)

40(18.5%)

0.68

3.682

0.448–1.031

0.055

 CT

GG

9 (4.5%)

24(11.1%)

0.543

3.908

0.285–1.034

0.048*

 TT

GG

4 (2.0%)

2 (0.9%)

2

0.183

0.393–10.181

0.669

rs12998782

rs10499859

 CC

AA

43(21.3%)

39(18.1%)

Reference

Reference

 CT

AA

31(15.3%)

17 (7.9%)

1.38

1.821

0.855–2.228

0.177

 TT

AA

5 (2.5%)

1 (0.5%)

4.167

1.087

0.507–34.218

0.297

 CC

AG

66(32.7%)

57(26.4%)

1.02

0.029

0.815–1.276

0.864

 CT

AG

32(15.8%)

40(18.5%)

0.843

0.981

0.599–1.185

0.322

 TT

AG

11 (5.4%)

5 (2.3%)

1.793

1.44

0.673–4.773

0.23

 CC

GG

8 (4.0%)

35(16.2%)

0.332

13.369

0.168–0.655

<0.001*

 CT

GG

3 (1.5%)

20 (9.2%)

0.192

11.324

0.061–0.608

0.001*

 TT

GG

3 (1.5%)

2 (0.9%)

1.337

0.108

0.235–7.609

0.742