Cryptococcosis in patients with hematological diseases: a 14-year retrospective clinical analysis in a Chinese tertiary hospital

Table 1 Summary of clinical characteristics of 33 cryptococcosis patients with hematological diseases

Variables	No. (%) of patients (N = 33)
Age, years	50 (range, 16–79)
Sex, female	19 (57.6)
Type of hematological diseases
Hematological malignancies	12 (36.4)
NHL	4 (12.1)
WM	3 (9.1)
ALL	1 (3.0)
CLL	1 (3.0)
HL	1 (3.0)
MM	1 (3.0)
MDS	1 (3.0)
Non-malignant hematological disorders	21 (63.6)
AIHA	10 (30.3)
Evans’ syndrome	6 (18.2)
ITP	5 (15.1)
Other underlying conditions
Chronic kidney diseases	2 (6.1)
Splenectomy	2 (6.1)
Rectal cancer	1 (3.0)
Chemotherapy	8 (24.2)
Glucocorticoids administration	28 (84.8)
Sites of cryptococcal infection^a
Brain	26 (78.8)
Lung	16 (48.5)
Blood	3 (9.1)
Sinus	2 (6.1)

NHL non-Hodgkin’s lymphoma; WM Waldenstrom’s macroglobulinemia; ALL acute lymphocytic leukemia; CLL chronic lymphocytic leukemia; HL Hodgkin’s lymphoma; MM multiple myeloma; MDS myelodysplastic syndrome; AIHA autoimmune hemolytic anemia; Evans’ Evans’ syndrome; ITP immune thrombocytopenia
^aSome of the patients had multi-site infection. Among 16 patients with lung infection, 9 had brain involvement as well. All patients with blood or sinus involvement had brain or lung infection at the same time

ISSN: 1471-2334