Table 1 Study 1. The performance characteristics of SOFIA®RSV, RSV DFA, and cell culture (MRC5)
Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | Positive predictive value (%) (95% CI) | Negative predictive value (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SOFIA RSV | DFA RSV | MRC5 RSV | SOFIA RSV | DFA RSV | MRC5 RSV | SOFIA RSV | DFA RSV | MRC5 RSV | SOFIA RSV | DFA RSV | MRC5 RSV | |
Total (n = 401) | 78.8 (70.6–85.7) | 63.4 (54.2–71.9) | 42.2 (33.4–51.5) | 98.5 (96.4–99.6) | 99.6 (98.0–100.0) | 99.6 (98.0–100.0) | 96.0 (90.2–98.9) | 98.7 (93.1–100.0) | 98.0 (89.9–100.0) | 91.3 (87.6–94.3) | 86.0 (81.7–89.6) | 79.6 (75.0–83.7) |
Infant group (n = 199) | 95.0 (86.8–98.1) | 81.0 (71.2–88.8) | 54.0 (43.0–65.0) | 99.0 (95.2–100.0) | 100.0 (97.4–100.0) | 100.0 (95.2–100.0) | 99.0 (93.3–100.0) | 100.0 (95.7–100.0) | 98.0 (88.7–100.0) | 96.6 (90.4–98.6) | 87.6 (80.8–92.8) | 74.3 (66.6–81.1) |
Children group (n = 100) | 45.0 (23.1–68.5) | 25.0 (8.7–49.1) | 30.0 (11.9–54.3) | 97.5 (91.3–99.7) | 98.7 (93.2–100.0) | 98.7 (96.3–100.0) | 82.0 (48.2–97.7) | 83.3 (35.9–99.6) | 100.0 (60.7–100.0) | 88.0 (79.0–93.7) | 84.0 (75.0–90.8) | 85.0 (76.3–91.6) |
Adult group (n = 102) | 59.0 (32.9–81.6) | 23.5 (6.8–49.9) | 0.0 (0.0–16.2) | 100.0 (96.5–100.0) | 100.0 (96.5–100.0) | 100.0 (96.5–100.0) | 100.0 (74.1–100.0) | 100.0 (47.3–100.0) | / | 92.0 (84.9–96.9) | 86.7 (78.4–92.7) | 83.0 (74.7–90.0) |