Table 1 Summary of case reports identified
From: Fusobacterial liver abscess: a case report and review of the literature
Age | Sex | Organism (specimen cultured) | Treatment | Single or multiple abscess(es) | Presumed source | |
|---|---|---|---|---|---|---|
1 [35] | 21 | M | F. nucleatum (abscess aspirate) | - Drainage of the two largest abscesses (R). - Piperacillin/tazobactam (UTP) - Ertapenem (8 weeks) | Multiple | Oropharynx (PF) |
2 [36] | 48 | M | F. nucleatum (abscess aspirate) | - Drainage of abscess (R) - Ceftriaxone and metronidazole (3 days) - IV penicillin and metronidazole (10 weeks) | Multiple | Oropharynx (PF) |
3 [37] | 23 | M | F. nucleatum (blood culture and abscess aspirate) | - Drainage of abscess (R) - Piperacillin/tazobactam (UTP) - Ertapenem (6 weeks) | Multiple | Unidentified |
4 [38] | 58 | M | F. nucleatum (abscess aspirate) | - Drainage of pelvic abscess (S) - Defunctioning colostomy - Ertapenem (6 weeks) - Low molecular weight heparin (2 weeks) | Multiple | Lower GI tract (diverticulitis) |
5 [39] | 48 | M | F. nucleatum (abscess aspirate) | - Drainage of two largest abscesses (R) - Piperacillin/tazobactam (14 days) - Moxifloxacin + oral penicillin (14 days) | Multiple | Unidentified |
6 [40] | 49 | M | F. nucleatum (abscess aspirate) | - Drainage of largest hepatic abscess(R) - Laparoscopic cholecystectomy - Laparoscopic appendicectomy - IV ertapenem (UTP) | Multiple | Oropharynx (PF) |
7 [41] | 59 | F | F. nucleatum, Treponema denticola, Prevotella intermedia, Porphyromonas gingivalis, Bacteroides vulgatus (tissue culture and abscess apsirate culture) | - None | Multiple | Oropharynx (PF) |
8 [28] | 59 | M | F. nucleatum (blood culture) | - Imipenem/cilastatin 500 mg BD (4 days) - Oral clindamycin 600 mg BD (UTP) | Single | Oropharynx (PF) |
9 [42] | 58 | M | F. nucleatum (abscess drainage) | - Drainage of hepatic abscess (R) - Oral ciprofloxacin, vancomycin, and gentamicin (UTP) - IV metronidazole (12 days) - Oral metronidazole (3 weeks) | Single | Oropharynx (PF) |
10 [43] | 24 | M | F. nucleatum (blood culture) | - IV metronidazole (4 weeks) - Oral metronidazole (2 weeks) | Single | Oropharynx (PLS) |
11 [44] | 62 | M | F. nucleatum (abscess aspirate) | - Drainage of abscess(NOS) - IV antibiotics (agent and time period not specified) | Single | Lower GI tract (biopsies) |
12 [45] | 78 | F | F. nucleatum (abscess aspirate) | - Drainage of hepatic abscess(R) - Drainage of subphrenic collection - Metronidazole (6 weeks) | Single | Lower GI tract (diverticular disease) |
13 [46] | 68 | M | F. nucleatum (blood cultures) | - IV cefotaxime 1 g Q8H and IV metronidazole 500 mg Q8H (24 days) - Oral metronidazole (2 weeks) - Enoxaparin 20 mg daily (UTP) | Single | Unidentified |
14 [47] | 54 | F | F. nucleatum (abscess aspirate) S. viridans (abscess aspirate) Actinomyces odontolyticus (abscess aspirate) | - Drainage of hepatic abscess (R) - Extraction of 11 teeth - IV antibiotics (agent and period of treatment unsepciified) | Multiple | Oropharynx (PF) |
15 [47] | 69 | M | F. nucleatum (abscess aspirate) | - Drainage of hepatic abscesses (R) - IV antibiotics (unspecified agent or time period) - Dental surgery | Multiple | Oropharynx (PF) |
16 [48] | 40 | M | F. nucleatum (blood culture) | - IV cefuroxime, metronidazole, and erythromycin (14 days) - Oral metronidazole (5 weeks) | Multiple | Unidentified |
17 [49] | 29 | M | F. nucleatum (abscess aspirate) | - Drainage of the largest abscess (R) - Metronidazole (10 days, route unspecified) - Open drainage other abscesses (S) - Oral metronidazole (4 weeks) | Multiple | Oropharynx (PF) |
18 [50] | 24 | M | Actinomyces israeli (abscess aspirate) F. nucleatum (Abscess aspirate) | - Open drainage of abscess (S) - Penicillin G 20 million units (4 weeks) - Oral penicillin (6 months) | Single | Unidentified |
19 [51] | 70 | M | F. nucleatum (abscess aspirate) | - Metronidazole (2 weeks, route unspecified) - Oral metronidazole (2 weeks) | Multiple | Unidentified |
20 [52] | 47 | M | F. nucleatum (tissue culture) Peptostreptococcus (tissue culture) | - Open resection of all three lesions. (S) - IV penicillin (3 weeks) - Repeat laparotomy 49 days later - PO penicillin (4 months) | Multiple | Unidentified |
21 [53] | 44 | F | F. nucleatum (blood culture) | - Drainage of abscess (R) - Imipenem and metronidazole (UTP) - Cefotaxime and metronidazole (13 days) - Ceftriaxone and oral metronidazole (5 weeks) | Single | Unidentified |
22 [54] | 60 | M | F. nucleatum (abscess aspirate) | - Piperacillin/tazobactam (3 days) - Ertapenem (1 day) - Moxifloxacin (10 days) - Metronidazole (3 weeks) | Multiple | Lower GI tract (diverticulitis) |
23 [55] | 28 | M | F. necrophorum (blood culture) | - Ceftriaxone (6 days) - Meropenem (14 days) | Single | Oropharynx (PLS) |
24 [56] | 30 | M | F. necrophorum (blood culture) | - Piperacillin/tazobactam and metronidazole (UTP) - Oral levofloxacin and metronidazole (UTP) | Multiple | Unidentified |
25 [57] | 48 | M | F. necrophorum (blood culture) | - Cefotiam (UTP) - Doripenem (19 days) - Oral levofloxacin (UTP) | Multiple | Oropharynx (PLS) |
26 [29] | 40 | M | F. necrophorum (tissue culture) | - Drainage of abscess (R) - Sulbactam/cefoperazone (10 days) - Meropenem (9 days) - Oral sawacillin (8 weeks) | Single | Unidentified |
27 [58] | 25 | M | F. necrophorum (blood culture) | - Piperacillin/tazobactam (UTP) - IV penicillin (6 weeks) | Single | Oropharynx (PLS) |
28 [59] | 34 | M | F. necrophorum (left subphrenic collection) | - Vancomycin and meropenem (UTP) - Tigecyclin and meropenem (UTP) - Tigecyclin (4 weeks) | Multiple | Upper GI tract (HPB) |
29 [60] | 44 | F | F. necrophorum (blood culture) | - IV ampicillin/sulbactam and ciprofloxacin (5 days) - IV ampicillin/sulbactam and metronidazole (13 days) - IV ampicillin/sulbactam (15 days) - Oral amoxicillin/clavulanate (1 month) | Single | Cervix |
30 [61] | 18 | M | F. necrophorum (blood culture) | - Aspiration of abscess (R) - Metronidazole and cefuroxime (UTP) - Piperacillin/tazobactam + clindamycin (5 weeks) | Single | Oropharynx (PLS) |
31 [62] | 21 | M | F. necrophorum (abscess drainage) F. nucleatum (peritonsillar abscess) | - Drainage of the largest hepatic abscess (R) - Piperacillin/tazobactam and metronidazole (6 weeks) | Multiple | Oropharynx (PLS) |
32 [10] | 25 | M | F. necrophorum (abscess aspirate) Prevotella spp. (blood culture and abscess aspirate) | - Drainage of abscess - Removal of diseased teeth - Oral amoxicillin/clavulanate (3 weeks) | SIngle | Oropharynx (PF) |
33 [11] | 64 | M | F. necrophorum (abscess aspirate) | - Aspiration of abscess (R) - Cefuroxime and metronidazole (2 weeks) - Oral metronidazole and oral ciprofloxacin (UTP) | Multiple | Lower GI tract (haemorrohoids) |
34 [63] | 22 | M | F. necrophorum (abscess aspirate) | - Aspiration of abscess (R) - Gentamicin, clarithormycin, metronidazole, ceftriaxone and low molecular weight heparin (6 weeks) | Multiple | Oropharynx (PLS) |
35 [64] | 19 | F | F. necrophorum (blood culture and abscess aspirate) | - Drainage of the largest hepatic abscess - IV benzylpenicillin, metronidazole, and ciprofloxacin (5 weeks) | Multiple | Oropharynx (PLS) |
36 [65] | 71 | M | F. necrophorum (abscess aspirate) | - IV benzylpenicillin (6 weeks) - Oral amoxicillin (6 weeks) | Multiple | Lower GI (diverticular disease) |
37 [66] | 44 | M | F. necrophorum (abscess aspirate) H. Parainfluenzae (abscess aspirate) | - Drainage of hepatic abscess (R) - IV tetracycline (3 days) - Co-trimoxazole (8 days) - IV cefazolin + IV gentamicin (UTP) - IV ceftriaxone (3 weeks) | Single | Unidentified |
38 [67] | 18 | M | F. necrophorum (blood culture) | - Cefotaxime, vancomycin, and azithromycin. Then cefepime and metronidazole (unspecified chronology or time period) | Single | Oropharynx (PLS) |
39 [68] | 17 | F | F. necrophorum (blood culture) | - Nafcillin and ceftriaxone (3 days) - Nafcillin, ceftriaxone, and metronidazole (6 weeks) | Multiple | Oropharynx (PLS) |
40 [69] | 27 | M | F. necrophorum (blood cultures and abscess aspirate) | - Drainage of hepatic abscess (R) - IV ampicillin, gentamicin, and metornidazole (10 days) - Oral ampicillin and metronidazole (5 weeks) | Single | Oropharynx (PLS) |
41 [70] | 55 | M | F. necrophorum (abscess aspirate) | - Aspiration of abscess - IV ampicillin/sulbactam (1 month) - Oral amoxicillin/clavulanate (21 days) | Multiple | Upper GI tract (HPB) |
42 [71] | 31 | M | F. necrophorum (abscess aspirate) | - Open drainage of abscesses (S) - Gentamicin, clindamycin, and doxicycline (15 days) - Further open drainage of abscess (S) - IV chloremphenicol and metronidazole (3 weeks) | Multiple | Unidentified |
43 [72] | 36 | M | F. necrophorum (abscess aspirate and blood culture) | - Drainage of hepatic abscesses (R) - Ceftriaxone 2 g Q24H (UTP) - Ampicillin/sulbactam 12 g/day (UTP) | Multiple | Oropharynx (PF) |
44 [73] | 57 | M | F. necrophorum (abscess aspirate) | - Drainage of abscess (R) - Metronidazole (7 days) and ceftriaxone (UTP) - Piperacillin/tazobactam (4 weeks) | Single | Oropharynx (PF) |
45 [74] | 34 | M | Fusobacterium spp. (abscess aspirate) | - Drainage of largest abscess with gentamicin flushes. (R) - Drainage of subdiaphragmatic collection (R) - Aspiration of smaller abscesses. (R) - Imipenem (22 days) | Multiple | Upper GI tract (Crohn’s Disease) |
46 [16] | 69 | M | Fusobacterium spp. (liver biopsy) | - Piperacillin and metronidazole (3 weeks) - Oral amoxicillin/clavulanate and metronidazole (2 months) | Multiple | Unidentified |
47 [75] | 41 | M | Fusobacterium spp. (abscess aspirate) | - Drainage of hepatic abscess (R) - Cefomandole, gentamicin, and metronidazole (UTP) - Penicillin (1 month) | Single | Upper GI tract (diverticulitis of terminal Ileum) |
48 [76] | 22 | M | Fusobacterium Spp (blood cultures) | - Penicillin (31 days) | Multiple | Unidentified |