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Table 1 Summary of case reports identified

From: Fusobacterial liver abscess: a case report and review of the literature

  Age Sex Organism (specimen cultured) Treatment Single or multiple abscess(es) Presumed source
1 [35] 21 M F. nucleatum
(abscess aspirate)
- Drainage of the two largest abscesses (R).
- Piperacillin/tazobactam (UTP)
- Ertapenem (8 weeks)
Multiple Oropharynx (PF)
2 [36] 48 M F. nucleatum
(abscess aspirate)
- Drainage of abscess (R)
- Ceftriaxone and metronidazole (3 days)
- IV penicillin and metronidazole (10 weeks)
Multiple Oropharynx (PF)
3 [37] 23 M F. nucleatum (blood culture and abscess aspirate) - Drainage of abscess (R)
- Piperacillin/tazobactam (UTP)
- Ertapenem (6 weeks)
Multiple Unidentified
4 [38] 58 M F. nucleatum (abscess aspirate) - Drainage of pelvic abscess (S)
- Defunctioning colostomy
- Ertapenem (6 weeks)
- Low molecular weight heparin (2 weeks)
Multiple Lower GI tract (diverticulitis)
5 [39] 48 M F. nucleatum (abscess aspirate) - Drainage of two largest abscesses (R)
- Piperacillin/tazobactam (14 days)
- Moxifloxacin + oral penicillin (14 days)
Multiple Unidentified
6 [40] 49 M F. nucleatum (abscess aspirate) - Drainage of largest hepatic abscess(R)
- Laparoscopic cholecystectomy
- Laparoscopic appendicectomy
- IV ertapenem (UTP)
Multiple Oropharynx (PF)
7 [41] 59 F F. nucleatum, Treponema denticola, Prevotella intermedia, Porphyromonas gingivalis, Bacteroides vulgatus (tissue culture and abscess apsirate culture) - None Multiple Oropharynx (PF)
8 [28] 59 M F. nucleatum (blood culture) - Imipenem/cilastatin 500 mg BD (4 days)
- Oral clindamycin 600 mg BD (UTP)
Single Oropharynx (PF)
9 [42] 58 M F. nucleatum (abscess drainage) - Drainage of hepatic abscess (R)
- Oral ciprofloxacin, vancomycin, and gentamicin (UTP)
- IV metronidazole (12 days)
- Oral metronidazole (3 weeks)
Single Oropharynx (PF)
10 [43] 24 M F. nucleatum (blood culture) - IV metronidazole (4 weeks)
- Oral metronidazole (2 weeks)
Single Oropharynx (PLS)
11 [44] 62 M F. nucleatum (abscess aspirate) - Drainage of abscess(NOS)
- IV antibiotics (agent and time period not specified)
Single Lower GI tract (biopsies)
12 [45] 78 F F. nucleatum (abscess aspirate) - Drainage of hepatic abscess(R)
- Drainage of subphrenic collection
- Metronidazole (6 weeks)
Single Lower GI tract (diverticular disease)
13 [46] 68 M F. nucleatum (blood cultures) - IV cefotaxime 1 g Q8H and IV metronidazole 500 mg Q8H (24 days)
- Oral metronidazole (2 weeks)
- Enoxaparin 20 mg daily (UTP)
Single Unidentified
14 [47] 54 F F. nucleatum (abscess aspirate)
S. viridans (abscess aspirate)
Actinomyces odontolyticus (abscess aspirate)
- Drainage of hepatic abscess (R)
- Extraction of 11 teeth
- IV antibiotics (agent and period of treatment unsepciified)
Multiple Oropharynx (PF)
15 [47] 69 M F. nucleatum (abscess aspirate) - Drainage of hepatic abscesses (R)
- IV antibiotics (unspecified agent or time period)
- Dental surgery
Multiple Oropharynx (PF)
16 [48] 40 M F. nucleatum (blood culture) - IV cefuroxime, metronidazole, and erythromycin (14 days)
- Oral metronidazole (5 weeks)
Multiple Unidentified
17 [49] 29 M F. nucleatum (abscess aspirate) - Drainage of the largest abscess (R)
- Metronidazole (10 days, route unspecified)
- Open drainage other abscesses (S)
- Oral metronidazole (4 weeks)
Multiple Oropharynx (PF)
18 [50] 24 M Actinomyces israeli (abscess aspirate)
F. nucleatum (Abscess aspirate)
- Open drainage of abscess (S)
- Penicillin G 20 million units (4 weeks)
- Oral penicillin (6 months)
Single Unidentified
19 [51] 70 M F. nucleatum (abscess aspirate) - Metronidazole (2 weeks, route unspecified)
- Oral metronidazole (2 weeks)
Multiple Unidentified
20 [52] 47 M F. nucleatum (tissue culture)
Peptostreptococcus (tissue culture)
- Open resection of all three lesions. (S)
- IV penicillin (3 weeks)
- Repeat laparotomy 49 days later
- PO penicillin (4 months)
Multiple Unidentified
21 [53] 44 F F. nucleatum
(blood culture)
- Drainage of abscess (R)
- Imipenem and metronidazole (UTP)
- Cefotaxime and metronidazole (13 days)
- Ceftriaxone and oral metronidazole (5 weeks)
Single Unidentified
22 [54] 60 M F. nucleatum (abscess aspirate) - Piperacillin/tazobactam (3 days)
- Ertapenem (1 day)
- Moxifloxacin (10 days)
- Metronidazole (3 weeks)
Multiple Lower GI tract (diverticulitis)
23 [55] 28 M F. necrophorum
(blood culture)
- Ceftriaxone (6 days)
- Meropenem (14 days)
Single Oropharynx (PLS)
24 [56] 30 M F. necrophorum (blood culture) - Piperacillin/tazobactam and metronidazole (UTP)
- Oral levofloxacin and metronidazole (UTP)
Multiple Unidentified
25 [57] 48 M F. necrophorum (blood culture) - Cefotiam (UTP)
- Doripenem (19 days)
- Oral levofloxacin (UTP)
Multiple Oropharynx (PLS)
26 [29] 40 M F. necrophorum (tissue culture) - Drainage of abscess (R)
- Sulbactam/cefoperazone (10 days)
- Meropenem (9 days)
- Oral sawacillin (8 weeks)
Single Unidentified
27 [58] 25 M F. necrophorum
(blood culture)
- Piperacillin/tazobactam (UTP)
- IV penicillin (6 weeks)
Single Oropharynx (PLS)
28 [59] 34 M F. necrophorum (left subphrenic collection) - Vancomycin and meropenem (UTP)
- Tigecyclin and meropenem (UTP)
- Tigecyclin (4 weeks)
Multiple Upper GI tract (HPB)
29 [60] 44 F F. necrophorum (blood culture) - IV ampicillin/sulbactam and ciprofloxacin (5 days)
- IV ampicillin/sulbactam and metronidazole (13 days)
- IV ampicillin/sulbactam (15 days)
- Oral amoxicillin/clavulanate (1 month)
Single Cervix
30 [61] 18 M F. necrophorum (blood culture) - Aspiration of abscess (R)
- Metronidazole and cefuroxime (UTP)
- Piperacillin/tazobactam + clindamycin (5 weeks)
Single Oropharynx (PLS)
31 [62] 21 M F. necrophorum (abscess drainage)
F. nucleatum (peritonsillar abscess)
- Drainage of the largest hepatic abscess (R)
- Piperacillin/tazobactam and metronidazole (6 weeks)
Multiple Oropharynx (PLS)
32 [10] 25 M F. necrophorum (abscess aspirate)
Prevotella spp. (blood culture and abscess aspirate)
- Drainage of abscess
- Removal of diseased teeth
- Oral amoxicillin/clavulanate (3 weeks)
SIngle Oropharynx (PF)
33 [11] 64 M F. necrophorum (abscess aspirate) - Aspiration of abscess (R)
- Cefuroxime and metronidazole (2 weeks)
- Oral metronidazole and oral ciprofloxacin (UTP)
Multiple Lower GI tract (haemorrohoids)
34 [63] 22 M F. necrophorum (abscess aspirate) - Aspiration of abscess (R)
- Gentamicin, clarithormycin, metronidazole, ceftriaxone and low molecular weight heparin (6 weeks)
Multiple Oropharynx (PLS)
35 [64] 19 F F. necrophorum (blood culture and abscess aspirate) - Drainage of the largest hepatic abscess
- IV benzylpenicillin, metronidazole, and ciprofloxacin (5 weeks)
Multiple Oropharynx (PLS)
36 [65] 71 M F. necrophorum (abscess aspirate) - IV benzylpenicillin (6 weeks)
- Oral amoxicillin (6 weeks)
Multiple Lower GI (diverticular disease)
37 [66] 44 M F. necrophorum (abscess aspirate)
H. Parainfluenzae (abscess aspirate)
- Drainage of hepatic abscess (R)
- IV tetracycline (3 days)
- Co-trimoxazole (8 days)
- IV cefazolin + IV gentamicin (UTP)
- IV ceftriaxone (3 weeks)
Single Unidentified
38 [67] 18 M F. necrophorum (blood culture) - Cefotaxime, vancomycin, and azithromycin. Then cefepime and metronidazole (unspecified chronology or time period) Single Oropharynx (PLS)
39 [68] 17 F F. necrophorum (blood culture) - Nafcillin and ceftriaxone (3 days)
- Nafcillin, ceftriaxone, and metronidazole (6 weeks)
Multiple Oropharynx (PLS)
40 [69] 27 M F. necrophorum (blood cultures and abscess aspirate) - Drainage of hepatic abscess (R)
- IV ampicillin, gentamicin, and metornidazole (10 days)
- Oral ampicillin and metronidazole (5 weeks)
Single Oropharynx (PLS)
41 [70] 55 M F. necrophorum (abscess aspirate) - Aspiration of abscess
- IV ampicillin/sulbactam (1 month)
- Oral amoxicillin/clavulanate (21 days)
Multiple Upper GI tract (HPB)
42 [71] 31 M F. necrophorum (abscess aspirate) - Open drainage of abscesses (S)
- Gentamicin, clindamycin, and doxicycline (15 days)
- Further open drainage of abscess (S)
- IV chloremphenicol and metronidazole (3 weeks)
Multiple Unidentified
43 [72] 36 M F. necrophorum (abscess aspirate and blood culture) - Drainage of hepatic abscesses (R)
- Ceftriaxone 2 g Q24H (UTP)
- Ampicillin/sulbactam 12 g/day (UTP)
Multiple Oropharynx (PF)
44 [73] 57 M F. necrophorum (abscess aspirate) - Drainage of abscess (R)
- Metronidazole (7 days) and ceftriaxone (UTP)
- Piperacillin/tazobactam (4 weeks)
Single Oropharynx (PF)
45 [74] 34 M Fusobacterium spp. (abscess aspirate) - Drainage of largest abscess with gentamicin flushes. (R)
- Drainage of subdiaphragmatic collection (R)
- Aspiration of smaller abscesses. (R)
- Imipenem (22 days)
Multiple Upper GI tract (Crohn’s Disease)
46 [16] 69 M Fusobacterium spp. (liver biopsy) - Piperacillin and metronidazole (3 weeks)
- Oral amoxicillin/clavulanate and metronidazole (2 months)
Multiple Unidentified
47 [75] 41 M Fusobacterium spp. (abscess aspirate) - Drainage of hepatic abscess (R)
- Cefomandole, gentamicin, and metronidazole (UTP)
- Penicillin (1 month)
Single Upper GI tract (diverticulitis of terminal Ileum)
48 [76] 22 M Fusobacterium Spp (blood cultures) - Penicillin (31 days) Multiple Unidentified
  1. PLS Pharyngitis/Lemierre’s syndrome, PF Periodontal flora, UTP Unspecified time period, IV Intravenous, BD twice daily, R radiological drainage, S surgical drainage