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Table 1 Demographic and clinical characteristics of young U.S. children with cystic fibrosis from 2003 to 2009, by pathogen acquisition status

From: Seasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis

  Respiratory Pathogen
MRSA S. maltophilia A. xylosoxidans H. influenzae
Acquired (n = 910) Negative (n = 3612) Acquired (n = 1161) Negative (n = 3361) Acquired (n = 228) Negative (n = 4294) Acquired (n = 2148) Negative (n = 2374)
Male (%) 445(49%) 1833(51%) 590(51%) 1688(50%) 98(43%) 2180(51%) 1062(49%) 1216(51%)
White (%) 825(91) 3326(92) 1065(92) 3086(92) 202(89) 3949(92) 1984(92) 2167(91)
Hispanic (%) 72(8) 427(12)* 148(13) 351(10)* 42(18) 457(11)* 208(10) 291(12)*
Identified by newborn screening (%) 280(31) 1618(45)* 423(36) 1475(44)* 73(32) 1825(43)* 806(38) 1092(46)*
Mean age at diagnosis, months (SD) 2.9(4.6) 2.4(4.3)* 2.6(4.3) 2.4(4.4) 3.5(5.3) 2.4(4.3)* 2.7(4.5) 2.3(4.2)*
ΔF508 mutation category (%)
 Homozygous 482(53) 1553(43)* 586(50) 1449(43)* 108(47) 1927(45) 996(46) 1039(44)
 Heterozygous 307(34) 1437(40) 390(34) 1354(40) 77(34) 1667(39) 802(37) 942(40)
 Other 79(9) 463(13) 132(11) 410(12) 32(14) 510(12) 255(12) 287(12)
CFTR functional classa (%)
 Severe 660(73) 2284(63)* 817(70) 2127(63)* 150(66) 2794(65) 1442(67) 1502(63)*
 Residual 61(7) 354(10) 70(6) 345(10) 12(5) 403(9) 198(9) 217(9)
 Unclassified 189(21) 974(27) 274(24) 889(26) 66(29) 1097(26) 508(24) 655(28)
  1. MRSA, methicillin-resistant Staphylococcus aureus; S. maltophilia, Stenotrophomonas maltophilia; A. xylosoxidans, Achromobacter xylosoxidans; H. influenzae, Haemophilus influenzae; SD, standard deviation; CFTR, cystic fibrosis transmembrane conductance regulator
  2. * P < 0.05 based on Student’s t test with unequal variances for continuous variables or χ2 test for categorical variables.
  3. a CFTR functional class is defined as follows: Severe, includes children in which CFTR mutations on both alleles result in minimal CFTR function (class 1, 2, or 3), including ΔF508; Residual, at least one allele with a mutation resulting in partial CFTR function (class 4 or 5); Unclassified, both alleles with unknown functional class, or one allele with minimal CFTR function and the second with unknown functional class