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Table 2 Distribution of different genotypes at ABCC2 rs 717,620 (−24 C > T), ABCC4 rs1751034 (3463 A > G) and ABCC10 rs2125739 (T > C) in patients treated with tenofovir with or without KTD

From: Clinical and genetic factors associated with kidney tubular dysfunction in a real-life single centre cohort of HIV-positive patients

  Overall population N = 158 Patients with KTD n = 42 Patients without KTD n = 116 p*
ABCC2 -24 C > T, rs717620 (%)
 C/C 104 65.8% 25 59.5% 79 68.1% 0.503
 C/T 52 32.9% 16 38.1% 36 31.0%
 T/T 2 1.3% 1 2.4% 1 0.9%
ABCC4 3463 A > G, rs1751034 (%)
 A/A 92 58.2% 27 64.3% 65 56.0% 0.010
 A/G 56 35.5% 9 21.4% 47 40.5%
 G/G 10 6.3% 6 14.3% 4 3.5%
ABCC10 rs2125739, T > C (%)
 T/T 80 50.6% 19 45.2% 61 52.6% 0.394
 T/C 66 41.8% 21 50.0% 45 38.8%
 C/C 12 7.6% 2 4.8% 10 8.6%
  1. Abbreviations: KTD kidney tubular dysfunction, ABCC ATP-binding cassette; *χ2