Table 2 Weighted VZV seroprevalence rates stratified by age in varicella-unvaccinated children 1–17 years of age, Germany
Anti-VZV IgG antibodies tested by ELISA, weighted seroprevalence rate [% (95%CI)] | Age in years | ||||||||
1 (n = 374) | 2 (n = 503) | 3 (n = 569) | 4 (n = 644) | 5 (n = 662) | 6 (n = 765) | 7 (n = 800) | 8 (n = 832) | 9 (n = 839) | |
Positive | 12.0 (8.1–17.4) | 25.2 (20.8–30.1) | 38.4 (33.5–43.5) | 60.1 (55.6–64.4) | 73.3 (68.9–77.2) | 85.7 (82.4–88.5) | 87.3 (84.4–89.8) | 89.6 (87.2–91.6) | 93.2 (90.5–95.1) |
Negative | 87.8 (82.4–91.7) | 74.4 (69.5–78.8) | 60.9 (55.8–65.7) | 39.4 (35.1–43.9) | 26.2 (22.3–30.6) | 14.0 (11.2–17.3) | 12.0 (9.6–14.9) | 9.4 (7.5–11.7) | 6.0 (4.2–8.6) |
Equivocal result | 0.2 (0.0–1.5) | 0.4 (0.1–1.5) | 0.7 (0.2–2.8) | 0.5 (0.2–1.5) | 0.5 (0.2–1.4) | 0.3 (0.1–0.8) | 0.6 (0.3–1.6) | 1.0 (0.5–2.0) | 0.8 (0.4–1.7) |
Anti-VZV IgG antibodies tested by ELISA, weighted seroprevalence rate [% (95%CI)] | Age in years | ||||||||
10 (n = 808) | 11 (n = 861) | 12 (n = 808) | 13 (n = 830) | 14 (n = 814) | 15 (n = 794) | 16 (n = 712) | 17 (n = 662) | Total (n = 12,277) | |
Positive | 94.1 (91.7–95.9) | 93.0 (90.5–94.9) | 93.7 (91.4–95.5) | 94.0 (91.6–95.7) | 94.5 (92.6–96.0) | 95.4 (93.5–96.8) | 96.4 (94.6–97.6) | 94.2 (91.8–96.0) | 80.3 (79.3–81.3) |
Negative | 5.4 (3.8–7.7) | 6.6 (4.8–9.0) | 5.0 (3.5–7.1) | 5.0 (3.5–7.2) | 4.5 (3.2–6.3) | 3.7 (2.5–5.5) | 3.3 (2.1–5.0) | 4.3 (2.8–6.6) | 18.9 (18.0–19.9) |
Equivocal result | 0.5 (0.2–1.2) | 0.4 (0.1–1.0) | 1.3 (0.7–2.5) | 1.0 (0.5–2.3) | 1.0 (0.5–1.9) | 0.8 (0.4–1.9) | 0.4 (0.1–1.2) | 1.5 (0.7–2.9) | 0.7 (0.6–0.9) |