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Table 4 Mutations associated with RMP and INH drug resistant TB among concordant Resistant result with Genotype MTBDRplus VER 2.0 and MGIT DST

From: Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples

RMP resistance INH resistance  
rpoB gene KatG gene inhA gene
WT1–8 missing Mutant WT missing Mutant WT1–2 missing Mutant Frequency
530–533 (WT8) S531L 315 S315TL - - 23
530–533 (WT8) S531L 315 - - - 3
526–529 (WT7) H526Y 315 S315TL - - 1
530–533 (WT8) S531L 315 - - - 1
526–529 (WT7) H526Y 315 S315TL -15,-16 (WT1) C15T 1
-8 (WT2) A16G
a510–513 (WT2) -      1
516–519 (WT4)       
522–526 (WT6)       
526–529 (WT7)       
a505–509 (WT1) -      1
513–517 (WT3)       
526–529 (WT7)       
530–533 (WT8)       
   b315 S315TL - - 3
   b315 - -15,-16 (WT1) - 1
  1. aMutations associated with RMP mono resistance, bMutations associated with INH mono resistance