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Table 3 Performance characteristics of Genotype MTBDRplus VER 2.0 LPA for detection RMP and INH resistance and MDR-TB in smear negative and culture positive direct sample, 2015

From: Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples

Detection of drug resistance MGIT R MGIT S LPA R LPA S Sensitivity% Specificity% PPV% NPV%
(95%* CI) (95%* CI) (95%* CI) (95%* CI)
*RMP 3 11 7 7 100 (29.2–100) 63.6 (30.8–89.1) 42.9 (9.9–81.6) 100 (59–100)
*INH 5 9 3 11 60 (14.7–94.7) 100 (66.4–100) 100 (29.2–100) 81.8 (48.2–97.7)
*MDR-TB (RMP&INH) 2 5 2 5 100 (15.8–100) 100 (47.8–100) 100 (15.8–100) 100 (47.8–100)
  1. *RMP Rifampicin, INH Isoniazid, MDR-TB Multidrug resistant Tuberculosis, CI Confidence Interval