|
Analysis
|
Virologic Failure or Other Discontinuation
|
Virologic Failure
|
Discontinuations due to Virologic Failure
|
Other Discontinuation
|
Virologic Suppression
|
|---|
|
aHR (95% CI)
|
p
|
aHR (95% CI)
|
p
|
aHR (95% CI)
|
p
|
aHR (95% CI)
|
p
|
aHR (95% CI)
|
p
|
|---|
|
0
|
Original Model
|
0.76 (0.56,1.03)
|
0.08
|
0.50 (0.28,0.91)
|
0.02
|
0.00 (0.00,0.00)
|
<.0001
|
0.93 (0.65,1.33)
|
0.68
|
0.99 (0.82,1.21)
|
0.96
|
|
1
|
Subgroup by Province
|
| |
ON/QC Only
|
0.73 (0.51,1.06)
|
0.10
|
0.90 (0.44,1.86)
|
0.78
|
0.00 (0.00,0.00)
|
<.0001
|
0.72 (0.47,1.11)
|
0.14
|
0.99 (0.78,1.27)
|
0.96
|
| |
BC Only
|
0.69 (0.34,1.42)
|
0.32
|
0.41 (0.09,1.78)
|
0.23
|
0.00 (0.00,0.00)
|
<.0001
|
0.93 (0.43,2.04)
|
0.86
|
0.78 (0.46,1.32)
|
0.35
|
|
2
|
Subgroup by Baseline VL
|
| |
< 100,000 copies/mL
|
0.66 (0.42,1.03)
|
0.07
|
0.47 (0.18,1.19)
|
0.11
|
0.00 (0.00,0.00)
|
<.0001
|
0.82 (0.49,1.36)
|
0.44
|
0.97 (0.76,1.23)
|
0.78
|
| |
≥ 100,000 copies/mL
|
0.86 (0.56,1.33)
|
0.49
|
0.54 (0.25,1.16)
|
0.11
|
0.00 (0.00,0.00)
|
<.0001
|
1.16 (0.68,2.00)
|
0.58
|
1.11 (0.81,1.53)
|
0.51
|
|
3
|
2010–2012 Only
|
0.81 (0.56,1.18)
|
0.27
|
0.55 (0.26,1.14)
|
0.11
|
0.00 (0.00,0.00)
|
<.0001
|
0.96 (0.63,1.48)
|
0.87
|
0.98 (0.76,1.26)
|
0.87
|
|
4
|
Simplification discontinuations included as competing risks
|
0.75 (0.54,1.03)
|
0.07
|
0.50 (0.28,0.91)
|
0.02
|
0.00 (0.00,0.00)
|
<.0001
|
0.92 (0.63,1.34)
|
0.65
|
0.99 (0.82,1.21)
|
0.96
|
|
5
|
SMC-FCS Imputation
|
0.76 (0.56, 1.04)
|
0.08
|
0.5 (0.28, 0.9)
|
0.02
|
0.00 (0.00,0.00)
|
<.0001
|
0.91 (0.62, 1.34)
|
0.64
|
0.98 (0.8, 1.2)
|
0.84
|
-
aHR adjusted hazard ratio, VL viral load
