Table 1 Performance of optimized PQ regimen options by region and assessed TDRs
TDR:0.125–0.375 mg/kg | Africa | Asia | Latin America | |||
Dose | Age | Accuracy | Age | Accuracy | Age | Accuracy |
(tablets) | (yrs) | (%) | (yrs) | (%) | (yrs) | (%) |
0.5p | 6mo-3 | 97.9 | 6mo-4 | 96.1 | 6mo-3 | 97.1 |
1p | 4–10 | 97.5 | 5–12 | 97.6 | 4–8 | 98.5 |
1a | 11–16 | 96.4 | 13–16 | 97.7 | 9–13 | 97 |
1a + 1p | 17+ | 99.6 | 17+ | 99.8 | 14+ | 99.1 |
97.9 | 97.8 | 97.9 | ||||
TDR:0.15–0.35 mg/kg | Africa | Asia | Latin America | |||
Dose | Age | Accuracy | Age | Accuracy | Age | Accuracy |
(tablets) | (yrs) | (%) | (yrs) | (%) | (yrs) | (%) |
0.5p | 6mo-3 | 88.2 | 6mo-3 | 92 | 6mo-2 | 94.8 |
1p | 4–10 | 90.3 | 4–11 | 92.9 | 3–8 | 90.3 |
1a | 11–15 | 91.4 | 12–16 | 89.3 | 9–13 | 91.1 |
1a + 1p | 16+ | 95.8 | 17+ | 98.6 | 14+ | 94 |
91.4 | 93.2 | 92.6 | ||||
TDR:0.1–0.4 mg/kg | Africa | Asia | Latin America | |||
Dose | Age | Accuracy | Age | Accuracy | Age | Accuracy |
(tablets) | (yrs) | (%) | (yrs) | (%) | (yrs) | (%) |
0.5p | 6mo-4 | 99.3 | 6mo-4 | 99.4 | 6mo-3 | 100 |
1p | 5–11 | 99.7 | 5–12 | 99.6 | 4–9 | 99.6 |
1a | 12–16 | 99.3 | 13–19 | 99.5 | 10–14 | 99.8 |
1a + 1p | 17+ | 100 | 20+ | 100 | 15+ | 100 |
99.6 | 99.6 | 99.9 | ||||