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Table 1 Performance of optimized PQ regimen options by region and assessed TDRs

From: Modelling the therapeutic dose range of single low dose primaquine to reduce malaria transmission through age-based dosing

TDR:0.125–0.375 mg/kg Africa Asia Latin America
Dose Age Accuracy Age Accuracy Age Accuracy
(tablets) (yrs) (%) (yrs) (%) (yrs) (%)
0.5p 6mo-3 97.9 6mo-4 96.1 6mo-3 97.1
1p 4–10 97.5 5–12 97.6 4–8 98.5
1a 11–16 96.4 13–16 97.7 9–13 97
1a + 1p 17+ 99.6 17+ 99.8 14+ 99.1
   97.9   97.8   97.9
TDR:0.15–0.35 mg/kg Africa Asia Latin America
Dose Age Accuracy Age Accuracy Age Accuracy
(tablets) (yrs) (%) (yrs) (%) (yrs) (%)
0.5p 6mo-3 88.2 6mo-3 92 6mo-2 94.8
1p 4–10 90.3 4–11 92.9 3–8 90.3
1a 11–15 91.4 12–16 89.3 9–13 91.1
1a + 1p 16+ 95.8 17+ 98.6 14+ 94
   91.4   93.2   92.6
TDR:0.1–0.4 mg/kg Africa Asia Latin America
Dose Age Accuracy Age Accuracy Age Accuracy
(tablets) (yrs) (%) (yrs) (%) (yrs) (%)
0.5p 6mo-4 99.3 6mo-4 99.4 6mo-3 100
1p 5–11 99.7 5–12 99.6 4–9 99.6
1a 12–16 99.3 13–19 99.5 10–14 99.8
1a + 1p 17+ 100 20+ 100 15+ 100
   99.6   99.6   99.9
  1. 0.5p = 1.875, 1p = 3.75 mg, 1a = 7.5 mg, 1a + 1p = 11.25 mg, PQ Primaquine, MO months. TDR Therapeutic Dose Range