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Table 2 Significantly modulated genes in spleen unique to V3000

From: Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

UniGene Gene Description Log2 Exp ± SEM
Genes uniquely modulated at 24 h pi
 Mm.389688 Oas1g 2′-5′ oligoadenylate synthetase 1G 4.50 ± 0.33
 Mm.218770 Ifi202b Interferon activated gene 202B 4.42 ± 0.41
 Mm.130 Socs1 Suppressor of cytokine signaling 1 4.26 ± 0.40
 Mm.461583 Zfp456 Zinc finger protein 456 3.77 ± 0.20
 Mm.271809 Daxx Fas death domain-associated protein 3.77 ± 0.16
 Mm.377095 Ly6f Lymphocyte antigen 6 complex, locus F 3.62 ± 0.26
 Mm.482110 Ly6c2 Lymphocyte antigen 6 complex, locus C2 3.56 ± 0.18
 Mm.312628 Serpina3g Serine (or cysteine) peptidase inhibitor, clade A, member 3G 3.25 ± 0.12
 Mm.20079 Calml3 Calmodulin-like 3 3.06 ± 0.41
 Mm.261270 Ifi204 Interferon activated gene 204 2.83 ± 0.06
Genes uniquely modulated at 48 h pi
 Mm.136573 Stfa3 Stefin A3 4.36 ± 0.42
 Mm.766 Cxcl9 Chemokine (C-X-C motif) ligand 9 3.85 ± 0.50
 Mm.390870 BC117090 CDNA sequence BC1179090 3.76 ± 0.16
 Mm.8369 Mst1 Macrophage stimulating 1 3.65 ± 0.34
 Mm.276739 Sox10 SRY-box containing gene 10 3.42 ± 0.25
 Mm.44176 Efemp1 Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 3.26 ± 0.24
 Mm.338001 Pld5 Phospholipase D family, member 5 3.07 ± 0.19
 Mm.272115 Myom2 Myomesin 2 3.03 ± 0.17
 Mm.1583 Ly6c1 Lymphocyte antigen 6 complex, locus C1 2.92 ± 0.09
 Mm.312628 Serpina3g Serine (or cysteine) peptidase inhibitor, clade A, member 3G 2.91 ± 0.19
Genes uniquely modulated at 72 h pi
 Mm.40965 Nt5c2 5′-nucleotidase, cytosolic II 3.61 ± 0.16
 Mm.136573 Stfa3 Stefin A3 3.41 ± 0.38
 Mm.312628 Serpina3g Serine (or cysteine) peptidase inhibitor, clade A, member 3G 3.11 ± 0.32
 Mm.482110 Ly6c2 Lymphocyte antigen 6 complex, locus C2 3.10 ± 0.19
 Mm.272115 Myom2 Myomesin 2 2.98 ± 0.28
 Mm.20079 Calml3 Calmodulin-like 3 2.92 ± 0.26
 Mm.359610 Stfa2 Stefin A2 2.86 ± 0.38
 Mm.276389 Hmox1 Heme oxygenase (decycling) 1 2.47 ± 0.25
 Mm.461583 Zfp456 Zinc finger protein 456 2.29 ± 0.41
 Mm.34609 Plac8 Placenta-specific 8 2.28 ± 0.09
  1. Genes that were uniquely modulated against V3000 infection in the spleen were identified. The list summarizes 10 genes with maximum amount of upregulation for each time point. Values are expressed as average values of (log2) fold expression for each gene over uninfected controls ± standard error mean (SEM). * P ≤ 0.05