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Table 2 Significantly modulated genes in spleen unique to V3000

From: Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

UniGene

Gene

Description

Log2 Exp ± SEM

Genes uniquely modulated at 24 h pi

 Mm.389688

Oas1g

2′-5′ oligoadenylate synthetase 1G

4.50 ± 0.33

 Mm.218770

Ifi202b

Interferon activated gene 202B

4.42 ± 0.41

 Mm.130

Socs1

Suppressor of cytokine signaling 1

4.26 ± 0.40

 Mm.461583

Zfp456

Zinc finger protein 456

3.77 ± 0.20

 Mm.271809

Daxx

Fas death domain-associated protein

3.77 ± 0.16

 Mm.377095

Ly6f

Lymphocyte antigen 6 complex, locus F

3.62 ± 0.26

 Mm.482110

Ly6c2

Lymphocyte antigen 6 complex, locus C2

3.56 ± 0.18

 Mm.312628

Serpina3g

Serine (or cysteine) peptidase inhibitor, clade A, member 3G

3.25 ± 0.12

 Mm.20079

Calml3

Calmodulin-like 3

3.06 ± 0.41

 Mm.261270

Ifi204

Interferon activated gene 204

2.83 ± 0.06

Genes uniquely modulated at 48 h pi

 Mm.136573

Stfa3

Stefin A3

4.36 ± 0.42

 Mm.766

Cxcl9

Chemokine (C-X-C motif) ligand 9

3.85 ± 0.50

 Mm.390870

BC117090

CDNA sequence BC1179090

3.76 ± 0.16

 Mm.8369

Mst1

Macrophage stimulating 1

3.65 ± 0.34

 Mm.276739

Sox10

SRY-box containing gene 10

3.42 ± 0.25

 Mm.44176

Efemp1

Epidermal growth factor-containing fibulin-like extracellular matrix protein 1

3.26 ± 0.24

 Mm.338001

Pld5

Phospholipase D family, member 5

3.07 ± 0.19

 Mm.272115

Myom2

Myomesin 2

3.03 ± 0.17

 Mm.1583

Ly6c1

Lymphocyte antigen 6 complex, locus C1

2.92 ± 0.09

 Mm.312628

Serpina3g

Serine (or cysteine) peptidase inhibitor, clade A, member 3G

2.91 ± 0.19

Genes uniquely modulated at 72 h pi

 Mm.40965

Nt5c2

5′-nucleotidase, cytosolic II

3.61 ± 0.16

 Mm.136573

Stfa3

Stefin A3

3.41 ± 0.38

 Mm.312628

Serpina3g

Serine (or cysteine) peptidase inhibitor, clade A, member 3G

3.11 ± 0.32

 Mm.482110

Ly6c2

Lymphocyte antigen 6 complex, locus C2

3.10 ± 0.19

 Mm.272115

Myom2

Myomesin 2

2.98 ± 0.28

 Mm.20079

Calml3

Calmodulin-like 3

2.92 ± 0.26

 Mm.359610

Stfa2

Stefin A2

2.86 ± 0.38

 Mm.276389

Hmox1

Heme oxygenase (decycling) 1

2.47 ± 0.25

 Mm.461583

Zfp456

Zinc finger protein 456

2.29 ± 0.41

 Mm.34609

Plac8

Placenta-specific 8

2.28 ± 0.09

  1. Genes that were uniquely modulated against V3000 infection in the spleen were identified. The list summarizes 10 genes with maximum amount of upregulation for each time point. Values are expressed as average values of (log2) fold expression for each gene over uninfected controls ± standard error mean (SEM). * P ≤ 0.05