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Table 1 Number of significantly modulated genes in spleen and brain

From: Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

  Spleen Brain
24 h pi 48 h pi 72 h pi 48 h pi 72 h pi 96 h pi
V3000
 Upregulated 136 255 241 75 57 210
 Downregulated 188 276 245 166 111 169
 Total 324 531 486 241 168 379
V3034
 Upregulated 58 252 210 62 79 71
 Downregulated 31 253 38 92 127 153
 Total 89 505 248 154 206 224
  1. Total RNA extracted from V3000 and V3034 infected spleen and brain was used to perform whole genome microarray as described in methods. Gene’s modulated in all the replicates (n = 3), ≥2.0 fold (i.e., log2 ratio ≥ 1.0 or ≤ −1.0) relative expression level over uninfected controls, and p-value ≤0.05 were considered significant
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BMC Infectious Diseases

ISSN: 1471-2334

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