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Table 5 Results of meta-analyses in Progressive Resistive Exercise (PRE) and HIV systematic review: strength outcomes

From: Effectiveness of Progressive Resistive Exercise (PRE) in the context of HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol

Outcomes

Sub-Group Comparison of Meta-Analysis

# of Individual Studies Included in Meta-Analysis

Number of Participants Included in Meta-Analysis

Weighted Mean Difference (WMD)

95% Confidence Interval

P value of overall effect

I2 statistic (p value for heterogeneity)

Interpretation

Chest Press (1-RM)

Combined PRE and aerobic exercise group compared with no exercise

2 studies

(Fitch 2012 [28]; Tiozzo 2011 [33])

44

11.86 kg 1-RMb

2.37, 21.36

0.01a

46%

(p = 0.18)

“Significant and potential clinically important improvement in change in chest press 1-repetition maximum among exercisers compared with non-exercisers.” [12].

Knee Flexion

(1-RM)

Combined PRE and aerobic exercise group compared with no exercise

3 studies

(Dolan 2006 [37], Fitch 2012 [28]; Grinspoon 2000) [39]

81

10.46 kg 1-RMb

1.64, 19.29

0.02a

91%

(p < 0.00001)

“Significant and potential clinical important improvement in change in knee flexion 1-repetition maximum among exercisers compared with non-exercisers” [12].

PRE (or combined PRE and aerobic exercise) and testosterone compared with testosterone alone

2 studies

(Grinspoon 2000 [39]; Sattler 1999 [42])

51

4.67 kg 1-RM

−1.98, 11.31

0.17

89% (p = 0.002)

Non-significant trend towards a greater increase in knee extension 1-RM among exercisers taking testosterone compared with non-exercisers taking testosterone only.

Leg Press

(1-RM)

Combined PRE and aerobic exercise group compared with no exercise

2 studies

(Fitch 2012 [28]; Tiozzo 2011 [33])

44

50.96 kg 1-RMb

−13.01, 114.92

0.12

88%

(p = 0.004)

“Non-significant trend towards an increase in leg press 1-RM among exercisers compared with non-exercisers.” [12].

Knee Extension

(1-RM)

Combined PRE and aerobic exercise group compared with no exercise

3 studies

(Dolan 2006 [37]; Fitch 2012 [28]; Grinspoon 2000 [39])

81

20.58 kg 1-RMb

−4.69, 45.86

0.11

95%

(p < 0.00001)

“Non-significant trend towards an increase in knee extension 1-RM among exercisers compared with non-exercisers.” [12].

PRE (or combined PRE and aerobic exercise) and testosterone compared with testosterone alone

2 studies

(Grinspoon 2000 [39]; Sattler 1999 [42])

51

13.09 kg 1-RMb

−9.94, 36.11

0.27

97%

(p < 0.00001)

Non-significant trend towards a greater increase in knee extension 1-RM among exercisers taking testosterone compared with non-exercisers taking testosterone alone.

  1. 1-RM 1 repetition maximum, PRE progressive resistive exercise
  2. aIndicates statistical significance; bindicates potential clinically important change in outcome
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BMC Infectious Diseases

ISSN: 1471-2334

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