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Table 3 Antibiotic management of ADI

From: Acute dental infections managed in an outpatient parenteral antibiotic program setting: prospective analysis and public health implications

OPAT ADI (n = 110)a
Antibiotic Management
 Received Pre-ED/UC PO antibiotics – n (%) 49 (45)  
 Days of OPAT IV - median (IQR) 3 [2]  
 Days of Post-OPAT PO – median (IQR) 9 [3]  
 Total OPAT & Post-OPAT days – median (IQR) 15 [4]  
Antibiotic Regime – n (%)
ED/UC prescription (IV) (n = 105)
 Cefazolin & metronidazoleb 60 (57)  
 Clindamycinc 22 [21]  
 Ceftriaxone & metronidazoleb 13 [12]  
 Other 10 [10]  
OPAT prescription (IV) (n = 108)
 Cefazolin & metronidazoleb 84 (78)  
 Ceftriaxone & metronidazoleb 14 [13]  
 Clindamycinc 10 [9]  
OPAT discharge prescription (PO) (n = 107)
 Cephalexin or cefadroxil both with metronidazole 64 (60)  
 Amoxicillin-clavulanic acid 24 [22]  
 Clindamycinc 16 [15]  
 Other 3 [3]  
Regime Specific Duration of Antibiotics – days
 Parenteral (IV)g   p = 0.2
 Narrow spectrum IV regime – mean (SD)d 4.2 (2.2)  
 Broad spectrum IV regime – mean (SD)e 3.2 (1.1)  
 Total course (IV & PO) (n = 107)   p = 0.4
 Narrow spectrum regimef – mean (SD) 14.9 (4.3)  
 Broad spectrum regime# – mean (SD) 15.2 (5.4)  
  1. ED emergency department, UC urgent care, IV intravenous, PO oral route, IQR interquartile range, SD standard deviation
  2. an = 110 unless otherwise specified
  3. bMetronidazole component in either PO or IV formulation
  4. cOf those receiving clindamycin 5 had clinical record of a beta-lactam allergy
  5. dNarrow spectrum IV regime = cefazolin or penicillin both with metronidazole, PO regime = amoxicillin or cephalexin or cefadroxil with metronidazole
  6. eBroad spectrum IV regime = clindamycin alone or ceftriaxone with metronidazole, PO regime = amoxicillin-clavulanic acid or clindamycin
  7. fDefined as majority of days of treatment consisting of either broad or narrow spectrum agents
  8. gExcluding cases where only a single initial dose of ceftriaxone was given and participants were then discharged on oral antibiotics