Acute dental infections managed in an outpatient parenteral antibiotic program setting: prospective analysis and public health implications

Table 3 Antibiotic management of ADI

OPAT ADI (n = 110)^a
Antibiotic Management
Received Pre-ED/UC PO antibiotics – n (%)	49 (45)
Days of OPAT IV - median (IQR)	3 [2]
Days of Post-OPAT PO – median (IQR)	9 [3]
Total OPAT & Post-OPAT days – median (IQR)	15 [4]
Antibiotic Regime – n (%)
ED/UC prescription (IV) (n = 105)
Cefazolin & metronidazole^b	60 (57)
Clindamycin^c	22 [21]
Ceftriaxone & metronidazole^b	13 [12]
Other	10 [10]
OPAT prescription (IV) (n = 108)
Cefazolin & metronidazole^b	84 (78)
Ceftriaxone & metronidazole^b	14 [13]
Clindamycin^c	10 [9]
OPAT discharge prescription (PO) (n = 107)
Cephalexin or cefadroxil both with metronidazole	64 (60)
Amoxicillin-clavulanic acid	24 [22]
Clindamycin^c	16 [15]
Other	3 [3]
Regime Specific Duration of Antibiotics – days
Parenteral (IV)^g		p = 0.2
Narrow spectrum IV regime – mean (SD)^d	4.2 (2.2)
Broad spectrum IV regime – mean (SD)^e	3.2 (1.1)
Total course (IV & PO) (n = 107)		p = 0.4
Narrow spectrum regime^f – mean (SD)	14.9 (4.3)
Broad spectrum regime# – mean (SD)	15.2 (5.4)

ED emergency department, UC urgent care, IV intravenous, PO oral route, IQR interquartile range, SD standard deviation
^an = 110 unless otherwise specified
^bMetronidazole component in either PO or IV formulation
^cOf those receiving clindamycin 5 had clinical record of a beta-lactam allergy
^dNarrow spectrum IV regime = cefazolin or penicillin both with metronidazole, PO regime = amoxicillin or cephalexin or cefadroxil with metronidazole
^eBroad spectrum IV regime = clindamycin alone or ceftriaxone with metronidazole, PO regime = amoxicillin-clavulanic acid or clindamycin
^fDefined as majority of days of treatment consisting of either broad or narrow spectrum agents
^gExcluding cases where only a single initial dose of ceftriaxone was given and participants were then discharged on oral antibiotics

ISSN: 1471-2334