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Table 2 Analysis of potential risk factors for excessively prolonged meropenem therapy

From: Risk factors for excessively prolonged meropenem use in the intensive care setting: a case-control study

   Univariate logistic regression Multivariate logistic regression
OR 95 % CI P-value OR 95% CI P-value
age <50 1   0.44 - - -
50-70 0.72 0.25–2.04
≥70 0.49 0.16–1.53
sex male 1   0.76 - - -
female 1.13 0.51–2.49
malignancy No 1   0.002 1   0.84
Yes 3.5 1.57–7.82 1.14 0.32–4.06
SAPS at admission <40 1   0.33 - - -
≥40 1.45 0.68–3.11
patient group medical 1   <0.001 1   0.31
neurological 2.41 0.63–9.30 2.79 0.65 – 11.92
surgical 8.36 2.67–26.17 2.46 0.50 – 11.98
colonization with carbapenem-susceptible, MDR bacteria no 1   0.01 1   0.004
yes 4.12 1.38–12.35 7.52 1.88–30.14
type of infection pneumonia 1   <0.001 1   <0.001
peritonitis 21.60 5.05–92.35 16.96 2.95 – 97.49
mediastinitis 10.12 1.96–52.41 6.27 0.81 – 48.76
unclear focus 0.94 0.27–3.24 0.77 0.21 – 2.84
  1. Full model containing all variables with at least some evidence of association (p < 0.1) with the outcome in univariate regression analysis
  2. Abbreviations: MDR multidrug-resistant; OR: odds ratio; 95% CI: 95% confidence Interval