Table 5 Correlation of the timing of fatal symptoms/signs with other symptoms/signs among seven non-survivors after EV-A71 infection with neurological involvement

N

27

115

39

8

12

74

28

16

162

211

17

14

Mean (hours)

52.9

44.0

40.1

57.5

49.6

35.0

40.2

51.8

33.3

30.0

44.2

45.7

SD

25.4

26.5

31.1

31.5

26.3

25.2

27.4

28.5

23.0

23.0

23.1

22.1

Range

18–114

0–136

0–136

12–120

24–120

0–96

0–96

18–99

0–96

0–84

0–96

0–72

p

Autokinetic eyeball

0

0.014

0.03

0.078

0

0.047

—

0.064

0.053

0.229

—

—

Ataxia eyeball

0.001

0.002

0.008

0.003

0

0.017

—

0.003

0.053

0.03

—

—

Ultrahyperpyrexia

0.002

—

—

—

0

—

0.002

—

—

—

—

—

Pharyngeal reflex decreased or absent

0.002

0.056

0.024

0.015

—

0.05

0.161

0.008

0.256

0.172

—

—

Respiratory rhythm abnormally

0

0.004

0.006

0

0

0.012

0.029

0.104

0.048

0.094

0.011

0.278

NPE

0

0

0.013

0.001

0

0.066

0.003

0.091

0.007

0.089

0.003

0.206

Severe coma

0

0.047

—

—

—

0.009

—

—

0.021

0.006

—

0.029

Excessive Tachycardia

0.001

0.034

0.024

—

—

0.454

0.061

0.033

0.127

0.412

—

—

Refractory shock

0

0.033

0.075

0.029

—

0.182

—

0.104

—

0.15

0.053

0.074

Ataxia respiratory

0

0.038

—

—

—

0.362

0.043

—

0.102

0.334

—

—

N (P < 0.05)

10

8

6

5

5

5

4

4

3

2

2

1