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Table 1 Baseline characteristics

From: The immunological response to syphilis differs by HIV status; a prospective observational cohort study

  Controls Primary/Secondary syphilis Latent Syphilis
(n = 30) HIV+ (n = 44)# HIV-(n = 10)# HIV+ vs. HIV-, P$ HIV+(n = 35)#
Men 30 (100%) 44 (100%) 9 (90%)* 0.0359 35 (100%)
Age (years) 37 (32–45) 39.5 (30.5–50.0) 34 (30–43) 0.4689 40 (35–46)
MSM 24 (80%) 44 (100%) 9 (90%) 0.0359 34 (94.7.1%)
CD4 T cell count (cells per μL) 577 (392–684) 649 (452–838) 800 (800–800) 0.4537 590 (433–691)
HIV Viral Load (copies per mL) 34 (10–814) 10 (10–53)* NA NA 10 (10–25)**
On Antiretroviral Therapy 24 (80%) 39 (88.6%) NA NA 31 (88.6%)
RPR titre 0 (0–0) 1/64 (1/32–1/128) 1/64 (1/16–1/128) 0.5556 1/64 (1/16–1/128)
Treatment     1.0  
Benzathine-penicillin G NA 44 (100%) 10 (100%)   33 (94.3%)
Doxycycline NA 0 0   2 (5.7%)
Previous treated syphilis NA 27 (61.3%) 3 (30%) 0.0743 24 (68.6%)
Other STIs presenta 0 (30) 1 (2.3%) 0 (0%) 0.63 2 (5.7%)
No. of sex partners prior 12 months 1.5 (1–6) 8.5 (2–26)** 6.5 (2–8)* 0.5174 7 (1–12)*
  1. Data are n (%), median (IQR), unless otherwise stated. NA - Not Applicable
  2. *P < 0.05, ** P < 0.005
  3. # P-value is for comparison with controls at baseline (Mann-Whitney U-test, excluding ‘Men’, ‘MSM’, ‘On Antiretroviral Therapy’ and ‘Other STIs’ where Fisher’s exact test used)
  4. $ P-value is for comparison between HIV-infected and uninfected groups (Mann-Whitney U-test, except ‘Men’, ‘MSM’, ‘Treatment’, ‘Previous treated syphilis’ and ‘Other STIs’ where Fisher’s exact test used)
  5. aPresence of N. gonorrhoeae or C. trachomatis in urethra, rectum or oropharynx
  6. MSM: men who have sex with men