| |
Controls
|
Primary/Secondary syphilis
|
Latent Syphilis
|
|---|
|
(n = 30)
|
HIV+ (n = 44)#
|
HIV-(n = 10)#
|
HIV+ vs. HIV-, P$
|
HIV+(n = 35)#
|
|---|
|
Men
|
30 (100%)
|
44 (100%)
|
9 (90%)*
|
0.0359
|
35 (100%)
|
|
Age (years)
|
37 (32–45)
|
39.5 (30.5–50.0)
|
34 (30–43)
|
0.4689
|
40 (35–46)
|
|
MSM
|
24 (80%)
|
44 (100%)
|
9 (90%)
|
0.0359
|
34 (94.7.1%)
|
|
CD4 T cell count (cells per μL)
|
577 (392–684)
|
649 (452–838)
|
800 (800–800)
|
0.4537
|
590 (433–691)
|
|
HIV Viral Load (copies per mL)
|
34 (10–814)
|
10 (10–53)*
|
NA
|
NA
|
10 (10–25)**
|
|
On Antiretroviral Therapy
|
24 (80%)
|
39 (88.6%)
|
NA
|
NA
|
31 (88.6%)
|
|
RPR titre
|
0 (0–0)
|
1/64 (1/32–1/128)
|
1/64 (1/16–1/128)
|
0.5556
|
1/64 (1/16–1/128)
|
|
Treatment
| | | |
1.0
| |
|
Benzathine-penicillin G
|
NA
|
44 (100%)
|
10 (100%)
| |
33 (94.3%)
|
|
Doxycycline
|
NA
|
0
|
0
| |
2 (5.7%)
|
|
Previous treated syphilis
|
NA
|
27 (61.3%)
|
3 (30%)
|
0.0743
|
24 (68.6%)
|
|
Other STIs presenta
|
0 (30)
|
1 (2.3%)
|
0 (0%)
|
0.63
|
2 (5.7%)
|
|
No. of sex partners prior 12 months
|
1.5 (1–6)
|
8.5 (2–26)**
|
6.5 (2–8)*
|
0.5174
|
7 (1–12)*
|
- Data are n (%), median (IQR), unless otherwise stated. NA - Not Applicable
- *P < 0.05, ** P < 0.005
-
#
P-value is for comparison with controls at baseline (Mann-Whitney U-test, excluding ‘Men’, ‘MSM’, ‘On Antiretroviral Therapy’ and ‘Other STIs’ where Fisher’s exact test used)
-
$
P-value is for comparison between HIV-infected and uninfected groups (Mann-Whitney U-test, except ‘Men’, ‘MSM’, ‘Treatment’, ‘Previous treated syphilis’ and ‘Other STIs’ where Fisher’s exact test used)
-
aPresence of N. gonorrhoeae or C. trachomatis in urethra, rectum or oropharynx
- MSM: men who have sex with men
