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Table 4 Risk factors associated with poor prognosis of HIV negative cryptococcal meningitis (CM) and tuberculous meningitis (TBM) patients

From: Comparison of clinical features and prognostic factors in HIV-negative adults with cryptococcal meningitis and tuberculous meningitis: a retrospective study

Cryptococcal meningitis (CM)
Variables Univariate analysis Multivariate analysis
Odds ratio 95% CI P-value Odds ratio 95% CI P-value
Ages>60y 5.946 2.493–14.183 <0.001 4.981 1.955–12.692 0.001
Altered mentation 4.533 1.763–11.656 0.002 5.054 1.592–16.046 0.006
Demyelination 7.270 2.560–20.646 <0.001    
CD4/CD8 ratio<1 8.475 2.831–25.378 <0.001 8.782 2.436–31.661 0.001
CrAg titer ≥1:1024 5.338 1.769–16.103 0.003 4.853 1.377–17.098 0.014
Tuberculous meningitis (TBM)
 Fever 9.659 1.208–77.252 0.033    
 Headache 0.139 0.042–0. 459 0.001 0.125 0.032–0.497 0.003
 Hydrocephalus 3.692 1.062–12.839 0.040 7.290 1.630–32.606 0.009
 Underlying diseases or factors≥3 6.817 1.927–19.869 0.002 6.899 1.766–26.949 0.005
  1. HIV human immunodeficiency virus, CrAg cryptococcal antigen, CI confidential intervals