Comparison of clinical features and prognostic factors in HIV-negative adults with cryptococcal meningitis and tuberculous meningitis: a retrospective study

Table 4 Risk factors associated with poor prognosis of HIV negative cryptococcal meningitis (CM) and tuberculous meningitis (TBM) patients

Cryptococcal meningitis (CM)
Variables	Univariate analysis			Multivariate analysis
Variables	Odds ratio	95% CI	P-value	Odds ratio	95% CI	P-value
Ages>60y	5.946	2.493–14.183	<0.001	4.981	1.955–12.692	0.001
Altered mentation	4.533	1.763–11.656	0.002	5.054	1.592–16.046	0.006
Demyelination	7.270	2.560–20.646	<0.001
CD4/CD8 ratio<1	8.475	2.831–25.378	<0.001	8.782	2.436–31.661	0.001
CrAg titer ≥1:1024	5.338	1.769–16.103	0.003	4.853	1.377–17.098	0.014
Tuberculous meningitis (TBM)
Fever	9.659	1.208–77.252	0.033
Headache	0.139	0.042–0. 459	0.001	0.125	0.032–0.497	0.003
Hydrocephalus	3.692	1.062–12.839	0.040	7.290	1.630–32.606	0.009
Underlying diseases or factors≥3	6.817	1.927–19.869	0.002	6.899	1.766–26.949	0.005

HIV human immunodeficiency virus, CrAg cryptococcal antigen, CI confidential intervals

ISSN: 1471-2334