Platelet counts modulate the quantitative relationship between hepatitis B viral DNA and surface antigen concentrations: a cross-sectional study of hematological, histological and viral factors

Table 2 Association of viral and host variables to quantitative HBsAg concentrations using linear regression

	Univariate Analysis			Multivariate Analysis
Variables	Regression coefficient	95% CI	P	Adjusted regression coefficient	95% CI	P
Age
	-0.015	(-0.024 ~ -0.006)	0.002	0.002	(-0.009 ~ 0.013)	0.678
Gender-Male
	-0.188	(-0.491 ~ 0.115)	0.224
ISHAK Fibrosis Stages
	-0.134	(-0.206 ~ -0.061)	<0.001	-0.125	(-0.203 ~ -0.48)	0.002
Piecemeal necrosis
	-0.098	(-0.223 ~ 0.038)	0.156
Confluent necrosis
	-0.073	(-0.210 ~ 0.064)	0.293
Focal (spotty) lytic necrosis, apoptosis and focal inflammation
	-0.064	(-0.207 ~ 0.078)	0.375
Portal inflammation
	-0.083	(0.197 ~ 0.031)	0.152
HBV DNA (log10 IU/ml)
	0.310	(0.258 ~ 0.363)	<0.001	0.267	(0.197 ~ 0.337)	<0.001
HBeAg
	0.709	(0.509 ~ 0.909)	<0.001	0.301	(0.045 ~ 0.566)	0.021
ALT
	0.000	(0.000 ~ 0.001)	0.23
AST
	0.001	(0.000 ~ 0.002)	0.144
Bilirubin
	-0.121	(-0.372 ~ 0.130)	0.343
Albumin
	-0.017	(-0.455 ~ 0.422)	0.94
GGT
	-0.002	(-0.006 ~ 0.001)	0.122
Platelet
	0.003	(0.001 ~ 0.005)	0.003	0.002	(0.000 ~ 0.005)	0.064
Hemoglobin
	-0.107	(-0.204 ~ -0.010)	0.03	-0.57	(-0.137 ~ 0.023)	0.162

ISSN: 1471-2334