Feasibility Study of HIV Sentinel Surveillance using PMTCT data in Cameroon: from Scientific Success to Programmatic Failure

Billong, Serge C.; Dee, Jacob; Fokam, Joseph; Nguefack-Tsague, Georges; Ekali, Gabriel L.; Fodjo, Raoul; Temgoua, Edith S.; Billong, Edson-Joan; Sosso, Samuel M.; Mosoko, Jembia J.; Monebenimp, Francisca; Ndjolo, Alexis; Bissek, Anne-Cecile Z-K.; Bolu, Omotayo; Elat, Jean-Bosco N.

doi:10.1186/s12879-016-2119-5

Table 5 Sensitivity and Specificity of PMTCT Site Laboratories in HIV testing

From: Feasibility Study of HIV Sentinel Surveillance using PMTCT data in Cameroon: from Scientific Success to Programmatic Failure

Performance Evaluation of PMTCT sites in HIV testing compared to National Reference Laboratory (NRL)
			Site location
Region			Rural				Urban				Total				Sensitivity (Se) Specificity (Sp)
			RESULTS FROM THE NATIONAL REFERENCE LABORATORY (NRL)												Sensitivity (Se) Specificity (Sp)
	Test Results		Positive	Negative	Indeterminate	Total	Positive	Negative	Indeterminate	Total	Positive	Negative	Indeterminate	Total
Adamawa	RESULTS PMTCT SITE LABORATORIES	Positive	13	3	0	16	14	1	0	15	27	4	31	31	Se = 81 · 8% Sp = 99 · 4%
		Negative	4	266	1	271	2	384	0	386	6	650	657	657
		Indeterminate	0	0	0	0	2	0	0	2	2	0	0	2
		Total	17	269	1	287	18	385	0	403	35	654	1	690
Centre		Positive	8	0	0	8	39	0	0	39	47	0	0	47	Se = 78 · 3% Sp = 100%
		Negative	8	180	1	189	5	257	0	262	13	437	1	451
		Indeterminate	1	0	1	2	0	7	0	7	1	7	1	9
		Total	17	180	2	199	44	264	0	308	61	444	2	507
East		Positive	16	1	1	18	15	0	0	15	31	1	1	33	Se = 79 · 5% Sp = 99 · 8%
		Negative	7	275	0	282	1	270	3	274	8	545	3	556
		Indeterminate	0	1	0	1	2	4	1	7	2	5	1	8
		Total	23	277	1	301	18	274	4	296	41	551	5	597
Far North		Positive	2	2	1	5	25	3	0	28	27	5	1	33	Se = 93 · 1% Sp = 99 · 2%
		Negative	0	255	0	255	2	340	0	342	2	595	0	597
		Indeterminate	0	0	1	1	0	0	2	2	0	0	3	3
		Total	2	257	2	261	27	343	2	372	29	600	4	633
Littoral		Positive	19	4	0	23	31	3	1	35	50	7	1	58	Se = 79 · 4% Sp = 98 · 8%
		Negative	4	224	1	229	9	339	3	351	13	563	4	580
		Indeterminate	1	1	0	2	1	5	1	7	2	6	1	9
		Total	24	229	1	254	41	347	5	393	65	576	6	647
North		Positive	7	0	1	8	15	3	0	18	22	3	1	26	Se = 71 · 0% Sp = 99 · 6%
		Negative	1	285	1	287	8	384	1	393	9	669	2	680
		Indeterminate	0	0	0	0	0	2	1	3	0	2	1	3
		Total	8	285	2	295	23	389	2	414	31	674	4	709
North-West		Positive	17	3	0	20	29	1	1	31	46	4	1	51	Se = 90 · 2% Sp = 99 · 3%
		Negative	2	267	1	270	3	344	1	348	5	611	2	618
		Indeterminate	0	2	0	2	0	1	0	1	0	3	0	3
		Total	19	272	1	292	32	346	2	380	51	618	3	672
West		Positive	13	1	0	14	13	1	0	14	26	2	0	28	Se = 100% Sp = 99 · 7%
		Negative	0	221	0	221	0	369	2	371	0	590	2	592
		Indeterminate	0	1	1	2	0	2	0	2	0	3	1	4
		Total	13	223	1	237	13	372	2	387	26	595	3	624
South		Positive	11	4	0	15	9	1	1	11	20	5	1	26	Se = 58 · 8% Sp = 99 · 7%
		Negative	7	128	0	135	7	193	0	200	14	321	0	335
		Indeterminate	0	2	0	2	0	0	0	0	0	2	0	2
		Total	18	134	0	152	16	194	1	211	34	328	1	363
South-West		Positive	18	2	0	20	36	5	0	41	54	7	0	61	Se = 83 · 1% Sp = 98 · 8%
		Negative	5	250	4	259	6	329	2	337	11	579	6	596
		Indeterminate	0	3	0	3	0	0	1	1	0	3	1	4
		Total	23	255	4	282	42	334	3	379	65	589	7	661
Total		Positive	124	20	3	147	226	18	3	247	350	38	6	394
		Negative	38	2351	9	2398	43	3209	12	3264	81	5560	21	5662
		Indeterminate	2	10	3	15	5	21	6	32	7	31	9	47
		Total	164	2381	15	2560	274	3248	21	3543	438	5629	36	6103
Results: Rural, Urban, National			Se = 76 · 5% Sp = 99 · 2%				Se = 84 · 0%; Sp = 99 · 4%				Se = 81 · 2%; Sp = 99 · 3%

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ISSN: 1471-2334

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