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Table 1 Characteristics of IPD patients in 10 prefectures in Japan (n = 291) from April 2013 to March 2015

From: Invasive pneumococcal disease among adults in Japan, April 2013 to March 2015: disease characteristics and serotype distribution

Variable n/Na (%)
Female 107/291 (37)
Median age; years (IQR) 70 (61-81)
Age group
 15–39 years 15/291 (5)
 40–64 years 86/291 (30)
65 years 190 (65)
BMI
 Normal or Healthy Weight (18.5 – 24.9) 139/248 (56)
 Overweight (25.0 and Above) 41/248 (17)
 Underweight (Below 18.5) 68/248 (27)
Smoking history 132/256 (52)
Alcohol abuse 39/257 (15)
Preceding influenza 11/192 (6)
Vaccination history of PPSV23 16/231 (7)
Comorbidities 202/281 (72)
 Chronic pulmonary disease 24/281 (9)
 Chronic heart disease 19/281 (7)
 Chronic liver disease 19/281 (7)
 Chronic kidney disease 17/281 (6)
 Diabetes mellitus 34/281 (12)
 Immunocompromised status 107/281 (38)
 Hyposplenia/asplenia 14/271 (5)
 Autoimmune disease 33/281 (12)
 Corticosteroid therapy 26/281 (9)
 Malignancy 56/281 (20)
 Solid cancer 37/281 (13)
 Hematologic cancer 17/281 (6)
 Anti-cancer agent 22/281 (8)
Clinical presentation
 Bacteremia without any focus 47/291 (16)
 Meningitis 46/291 (16)
 Bacteremic pneumonia 173/291 (59)
 Othersb 25/291 (9)
Serotype
 PCV13 type 135/291 (46)
 PPSV23 type 191/291 (66)
Outcomec
 Fatal 57/291 (20)
  1. IQR Interquartile range, BMI Body mass index, PPSV23 23-valent pneumococcal polysaccharide vaccine
  2. a Number of available answers
  3. b Others included bacteremic arthritis, bacteremic cellulitis, bacteremic spondylitis bacteremic cholangitis, bacteremic empyema, infected aortic aneurysm and infective endocarditis
  4. c The case fatality was defined as reporting of death by the case-reporting form at the time of reporting