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Table 2 DEGs in plasma before HCV infection in clearance group compared to those in chronically infected group

From: Identification of the transcripts associated with spontaneous HCV clearance in individuals co-infected with HIV and HCV

DEGsa Gene function Fold difference P value FDR
AD000091.2 Uncharacterized 563.4 2.83E–07 0.001188912
C11orf95 Chromosome 11 open reading frame 95. Diseases associated with C11orf95 include ependymoma and chondroid lipoma. 100.9 5.80E–07 0.001188912
LPAR1 Lysophosphatidic acid receptor 1. Its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. 20 6.66E–07 0.001188912
LBR Lamin B receptor. Its related pathways are Metabolism and Metabolism. 20.6 2.85E–06 0.003815476
GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. Its related pathways are GPCR Pathway and GPCR Pathway. 7.6 9.21E–06 0.008563212
HOXD13 Homeobox D13. This gene is related to sequence-specific DNA binding transcription factor activity and chromatin binding. 231.4 9.61E–06 0.008563212
EARS2 Glutamyl-tRNA synthetase 2, mitochondrial. Its related pathways are Metabolism and Gene Expression. 22.6 1.17E–05 0.008563212
PRDM13 PR domain containing 13. This gene related to methyltransferase activity. 30.4 1.28E–05 0.008563212
RAB11FIP5 RAB11 family interacting protein 5 (class I). Its related pathways are Endocytosis and Delta508-CFTR traffic/ER-to-Golgi in CF. 23 2.52E–05 0.013834245
CTC-504A5.1 Affiliated with the ncRNA class 16.6 2.58E–05 0.013834245
CHST10 Carbohydrate sulfotransferase 10. Its related pathways are Other types of O-glycan biosynthesis and Biological oxidations. 8.9 4.28E–05 0.019890845
PRPSAP1 Phosphoribosyl pyrophosphate synthetase-associated protein 1. This gene is related to magnesium ion binding and enzyme inhibitor activity. 10 4.46E–05 0.019890845
TLX3 T-cell leukemia homeobox 3. Its related pathways are Transcriptional misregulation in cancer and SIDS Susceptibility Pathways. 103.6 5.11E–05 0.021040208
RP11-259G18.1 Uncharacterized 21.7 7.50E–05 0.024582733
DAZ4 Deleted in azoospermia 1. This gene is related to this gene include RNA binding and nucleotide binding. 7 7.68E–05 0.024582733
TMEM52 Transmembrane protein 52 50.8 7.68E–05 0.024582733
AC007879.2 Uncharacterized 13.3 7.93E–05 0.024582733
PCMTD2 Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2. This gene is related to protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. 10.4 8.26E–05 0.024582733
HNF1A-AS1 HNF1A antisense RNA 1 affiliated with the antisense RNA class. 13.6 8.86E–05 0.024984166
SUV420H2_1 Uncharacterized 21.7 9.76E–05 0.026140534
ATP6V1G2 ATPase, H+ transporting, lysosomal 13 kDa, V1 subunit G2. A multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. 27.3 1.06E–04 0.027114541
TCP10L T-complex 10-like. An important paralog of this gene is TCP10L2. 13.9 1.23E–04 0.028632706
MCU Mitochondrial calcium uniporter. It is related to calcium channel activity and uniporter activity. 7.8 1.23E–04 0.028632706
ZFHX3 Zinc finger homeobox 3. Its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell. 8 1.59E–04 0.035570625
RP11-508 M8.1 Uncharacterized 10.7 1.85E–04 0.039536736
CCL3 Chemokine (C-C motif) ligand 3. Its related pathways are Signaling by GPCR and TGF-Beta Pathway. 31 2.13E–04 0.043901777
LL22NC03-63E9.3 Uncharacterized LOC648691, affiliated with the ncRNA class. −22.2 2.30E–04 0.045120747
RP11-180P8.3 Uncharacterized 46.1 2.36E–04 0.045120747
RP11-213H15.3 Uncharacterized 11.1 2.56E–04 0.046011494
IL17D Interleukin 17D. Its related pathways are IL-17 Family Signaling Pathways and IL-17 Family Signaling Pathways. 40 2.58E–04 0.046011494
AC016831.7 Uncharacterized 5.8 2.71E–04 0.04688832
NFKBIL1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 8 2.98E–04 0.049193252
SLC2A6 Solute carrier family 2, member 6. Its related pathways are PAK Pathway and HIF1Alpha Pathway. 7.9 3.03E–04 0.049193252
  1. aDEG Differentially expressed gene