Table 2 DEGs in plasma before HCV infection in clearance group compared to those in chronically infected group
DEGsa | Gene function | Fold difference | P value | FDR |
|---|---|---|---|---|
AD000091.2 | Uncharacterized | 563.4 | 2.83E–07 | 0.001188912 |
C11orf95 | Chromosome 11 open reading frame 95. Diseases associated with C11orf95 include ependymoma and chondroid lipoma. | 100.9 | 5.80E–07 | 0.001188912 |
LPAR1 | Lysophosphatidic acid receptor 1. Its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. | 20 | 6.66E–07 | 0.001188912 |
LBR | Lamin B receptor. Its related pathways are Metabolism and Metabolism. | 20.6 | 2.85E–06 | 0.003815476 |
GNAI1 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. Its related pathways are GPCR Pathway and GPCR Pathway. | 7.6 | 9.21E–06 | 0.008563212 |
HOXD13 | Homeobox D13. This gene is related to sequence-specific DNA binding transcription factor activity and chromatin binding. | 231.4 | 9.61E–06 | 0.008563212 |
EARS2 | Glutamyl-tRNA synthetase 2, mitochondrial. Its related pathways are Metabolism and Gene Expression. | 22.6 | 1.17E–05 | 0.008563212 |
PRDM13 | PR domain containing 13. This gene related to methyltransferase activity. | 30.4 | 1.28E–05 | 0.008563212 |
RAB11FIP5 | RAB11 family interacting protein 5 (class I). Its related pathways are Endocytosis and Delta508-CFTR traffic/ER-to-Golgi in CF. | 23 | 2.52E–05 | 0.013834245 |
CTC-504A5.1 | Affiliated with the ncRNA class | 16.6 | 2.58E–05 | 0.013834245 |
CHST10 | Carbohydrate sulfotransferase 10. Its related pathways are Other types of O-glycan biosynthesis and Biological oxidations. | 8.9 | 4.28E–05 | 0.019890845 |
PRPSAP1 | Phosphoribosyl pyrophosphate synthetase-associated protein 1. This gene is related to magnesium ion binding and enzyme inhibitor activity. | 10 | 4.46E–05 | 0.019890845 |
TLX3 | T-cell leukemia homeobox 3. Its related pathways are Transcriptional misregulation in cancer and SIDS Susceptibility Pathways. | 103.6 | 5.11E–05 | 0.021040208 |
RP11-259G18.1 | Uncharacterized | 21.7 | 7.50E–05 | 0.024582733 |
DAZ4 | Deleted in azoospermia 1. This gene is related to this gene include RNA binding and nucleotide binding. | 7 | 7.68E–05 | 0.024582733 |
TMEM52 | Transmembrane protein 52 | 50.8 | 7.68E–05 | 0.024582733 |
AC007879.2 | Uncharacterized | 13.3 | 7.93E–05 | 0.024582733 |
PCMTD2 | Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2. This gene is related to protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. | 10.4 | 8.26E–05 | 0.024582733 |
HNF1A-AS1 | HNF1A antisense RNA 1 affiliated with the antisense RNA class. | 13.6 | 8.86E–05 | 0.024984166 |
SUV420H2_1 | Uncharacterized | 21.7 | 9.76E–05 | 0.026140534 |
ATP6V1G2 | ATPase, H+ transporting, lysosomal 13 kDa, V1 subunit G2. A multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. | 27.3 | 1.06E–04 | 0.027114541 |
TCP10L | T-complex 10-like. An important paralog of this gene is TCP10L2. | 13.9 | 1.23E–04 | 0.028632706 |
MCU | Mitochondrial calcium uniporter. It is related to calcium channel activity and uniporter activity. | 7.8 | 1.23E–04 | 0.028632706 |
ZFHX3 | Zinc finger homeobox 3. Its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell. | 8 | 1.59E–04 | 0.035570625 |
RP11-508 M8.1 | Uncharacterized | 10.7 | 1.85E–04 | 0.039536736 |
CCL3 | Chemokine (C-C motif) ligand 3. Its related pathways are Signaling by GPCR and TGF-Beta Pathway. | 31 | 2.13E–04 | 0.043901777 |
LL22NC03-63E9.3 | Uncharacterized LOC648691, affiliated with the ncRNA class. | −22.2 | 2.30E–04 | 0.045120747 |
RP11-180P8.3 | Uncharacterized | 46.1 | 2.36E–04 | 0.045120747 |
RP11-213H15.3 | Uncharacterized | 11.1 | 2.56E–04 | 0.046011494 |
IL17D | Interleukin 17D. Its related pathways are IL-17 Family Signaling Pathways and IL-17 Family Signaling Pathways. | 40 | 2.58E–04 | 0.046011494 |
AC016831.7 | Uncharacterized | 5.8 | 2.71E–04 | 0.04688832 |
NFKBIL1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | 8 | 2.98E–04 | 0.049193252 |
SLC2A6 | Solute carrier family 2, member 6. Its related pathways are PAK Pathway and HIF1Alpha Pathway. | 7.9 | 3.03E–04 | 0.049193252 |