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Table 3 Clinical and radiographic characteristics of patients with pulmonarya tuberculosis caused by Mycobacterium bovis or Mycobacterium tuberculosis, Mexico City, 2000–2015

From: Human tuberculosis caused by Mycobacterium bovis: a retrospective comparison with Mycobacterium tuberculosis in a Mexican tertiary care centre, 2000–2015

 

Etiological agent

 

Characteristic

M. bovis

(n = 94)

M. tuberculosis

(n = 260)

p b

Age, years, median (IQR)

39 (30–51)

46 (30–64)

0.0053c

Sex (female)

33/94 (35.1)

99/260 (38)

0.61

Healthcare worker

3/88 (3.4)

15/255 (5.8)

0.37

Farm worker

2/88 (2.2)

22/255 (8.6)

0.044

Low socioeconomic status

9/94 (9.5)

49/260 (18.8)

0.037

BCG-vaccinated

42/63 (66.6)

130/186 (69.8)

0.63

Contact with TB-infected people

11/80 (13.7)

48/235 (20.4)

0.18

Resides in high-prevalence region of bovine TBd

83/93 (89.2)

209/259 (80.6)

0.06

Alcohol intake ≥ 40 g/dayay

5/89 (5.6)

30/251 (11.9)

0.09

Unpasteurized dairy products consumption

2/10 (20)

8/17 (47)

0.16

Smoker (present)

50/89 (56.1)

103/253 (40.7)

0.012

HIV coinfection

26/94 (27.6)

63/260 (24.2)

0.51

CD4 count ≤200 cells/mm3

20/21 (95.2)

46/51 (90.2)

0.48

Diabetes mellitus

20/94 (21.2)

60/260 (23)

0.72

Connective tissue diseasee

17/94 (18)

28/260 (10.7)

0.068

Charlson comorbidity index ≥3

46/94 (48.9)

121/260 (46.5)

0.69

Glucocorticoid usef

25/94 (26.6)

37/260 (14.2)

0.007

Symptom onset to diagnosis, days, median (IQR)

62 (35–131)

80 (33–182)

0.15g

Presenting symptoms

 Fever

75/93 (80.6)

194/255 (76)

0.36

 Weight loss

48/93 (51.6)

137/255 (53.7)

0.72

 Cough

47/93 (50.5)

171/255 (67)

0.005

 Haemoptysis

5/93 (5.3)

26/255 (10.2)

0.16

 Dyspnoea

25/93 (26.8)

81/255 (31.7)

0.38

Chest radiography pattern

 Normal

13/79 (16.4)

19/242 (7.8)

0.027

 Cavitary

9/79 (11.3)

33/242 (13.6)

0.6

 Miliary

30/79 (37.9)

63/242 (26)

0.042

 Pleural effusion

17/79 (21.5)

40/242 (16.5)

0.31

 Consolidation

13/79 (16.4)

65/242 (26.8)

0.061

 Nodule

1/79 (1.2)

23/242 (9.5)

0.013h

 Interstitial

1/79 (1.2)

10/242 (4.1)

0.3h

 Respiratory sample positive smear

39/88 (44.3)

132/252 (52.3)

0.19

  1. Data are n/N (%) of cases, unless otherwise indicated. n values across categories might be less than the counts in the column headings due to missing data
  2. IQR Interquartile range, BCG Bacillus Calmette-Guérin, TB Tuberculosis, HIV Human immunodeficiency virus
  3. aExcludes cases that involved extrapulmonary disease only
  4. bp values were determined by the χ2 test
  5. cp value was determined by Student’s t-test
  6. dAs determined by SENASICA
  7. eSystemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, dermatomyositis, ankylosing spondylitis, mixed connective tissue disease, systemic sclerosis
  8. f ≥ 15 mg/d of prednisone or equivalent dose of steroids for 1 month or more in the year prior to TB diagnosis
  9. gp value was determined by the Mann–Whitney U test
  10. hp values were determined by Fisher’s exact test
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BMC Infectious Diseases

ISSN: 1471-2334

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