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Table 3 Clinical and radiographic characteristics of patients with pulmonarya tuberculosis caused by Mycobacterium bovis or Mycobacterium tuberculosis, Mexico City, 2000–2015

From: Human tuberculosis caused by Mycobacterium bovis: a retrospective comparison with Mycobacterium tuberculosis in a Mexican tertiary care centre, 2000–2015

  Etiological agent  
Characteristic M. bovis
(n = 94)
M. tuberculosis
(n = 260)
p b
Age, years, median (IQR) 39 (30–51) 46 (30–64) 0.0053c
Sex (female) 33/94 (35.1) 99/260 (38) 0.61
Healthcare worker 3/88 (3.4) 15/255 (5.8) 0.37
Farm worker 2/88 (2.2) 22/255 (8.6) 0.044
Low socioeconomic status 9/94 (9.5) 49/260 (18.8) 0.037
BCG-vaccinated 42/63 (66.6) 130/186 (69.8) 0.63
Contact with TB-infected people 11/80 (13.7) 48/235 (20.4) 0.18
Resides in high-prevalence region of bovine TBd 83/93 (89.2) 209/259 (80.6) 0.06
Alcohol intake ≥ 40 g/dayay 5/89 (5.6) 30/251 (11.9) 0.09
Unpasteurized dairy products consumption 2/10 (20) 8/17 (47) 0.16
Smoker (present) 50/89 (56.1) 103/253 (40.7) 0.012
HIV coinfection 26/94 (27.6) 63/260 (24.2) 0.51
CD4 count ≤200 cells/mm3 20/21 (95.2) 46/51 (90.2) 0.48
Diabetes mellitus 20/94 (21.2) 60/260 (23) 0.72
Connective tissue diseasee 17/94 (18) 28/260 (10.7) 0.068
Charlson comorbidity index ≥3 46/94 (48.9) 121/260 (46.5) 0.69
Glucocorticoid usef 25/94 (26.6) 37/260 (14.2) 0.007
Symptom onset to diagnosis, days, median (IQR) 62 (35–131) 80 (33–182) 0.15g
Presenting symptoms
 Fever 75/93 (80.6) 194/255 (76) 0.36
 Weight loss 48/93 (51.6) 137/255 (53.7) 0.72
 Cough 47/93 (50.5) 171/255 (67) 0.005
 Haemoptysis 5/93 (5.3) 26/255 (10.2) 0.16
 Dyspnoea 25/93 (26.8) 81/255 (31.7) 0.38
Chest radiography pattern
 Normal 13/79 (16.4) 19/242 (7.8) 0.027
 Cavitary 9/79 (11.3) 33/242 (13.6) 0.6
 Miliary 30/79 (37.9) 63/242 (26) 0.042
 Pleural effusion 17/79 (21.5) 40/242 (16.5) 0.31
 Consolidation 13/79 (16.4) 65/242 (26.8) 0.061
 Nodule 1/79 (1.2) 23/242 (9.5) 0.013h
 Interstitial 1/79 (1.2) 10/242 (4.1) 0.3h
 Respiratory sample positive smear 39/88 (44.3) 132/252 (52.3) 0.19
  1. Data are n/N (%) of cases, unless otherwise indicated. n values across categories might be less than the counts in the column headings due to missing data
  2. IQR Interquartile range, BCG Bacillus Calmette-Guérin, TB Tuberculosis, HIV Human immunodeficiency virus
  3. aExcludes cases that involved extrapulmonary disease only
  4. bp values were determined by the χ2 test
  5. cp value was determined by Student’s t-test
  6. dAs determined by SENASICA
  7. eSystemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, dermatomyositis, ankylosing spondylitis, mixed connective tissue disease, systemic sclerosis
  8. f ≥ 15 mg/d of prednisone or equivalent dose of steroids for 1 month or more in the year prior to TB diagnosis
  9. gp value was determined by the Mann–Whitney U test
  10. hp values were determined by Fisher’s exact test