Table 1 Designated and estimated prevalence of the 14 high-risk virus types by Linear Array (LA)-only, Hybrid Capture (HC2)-only, and sequential testing strategies in the United States and Latin America

Sen = 1.00

Spe = 1.00

Baseline

0.287 (0.007)

0.287 (0.007)

1.000

0.180 (0.006)

0.628

0.129 (0.005)

0.446

Reduced

0.265 (0.007)

0.265 (0.007)

1.000

0.172 (0.006)

0.657

0.124 (0.005)

0.468

% Reduction

7.6

7.6

0.3

3.9

Sen = 0.95

Spe = 0.95

Baseline

0.287 (0.007)

0.612 (0.008)

2.132

0.303 (0.007)

1.056

0.275 (0.007)

0.958

Reduced

0.265 (0.007)

0.602 (0.008)

2.272

0.299 (0.007)

1.128

0.271 (0.007)

1.023

% Reduction

7.6

1.6

1.3

1.5

Sen = 0.95

Spe = 0.90

Baseline

0.287 (0.007)

0.792 (0.006)

2.760

0.371 (0.008)

1.293

0.356 (0.008)

1.240

Reduced

0.265 (0.007)

0.787 (0.007)

2.970

0.369 (0.008)

1.392

0.354 (0.008)

1.340

% Reduction

8.0

0.6

0.5

0.6

Sen = 0.90

Spe = 0.90

Baseline

0.287 (0.007)

0.788 (0.006)

2.746

0.370 (0.007)

1.289

0.355 (0.007)

1.237

Reduced

0.265 (0.007)

0.783 (0.007)

2.955

0.368 (0.007)

1.389

0.352 (0.002)

1.328

% Reduction

7.7

0.6

0.5

0.8

Sen = 0.90

Spe = 0.85

Baseline

0.287 (0.007)

0.887 (0.005)

3.091

0.407 (0.008)

1.418

0.399 (0.008)

1.390

Reduced

0.265 (0.007)

0.885 (0.005)

3.340

0.405 (0.008)

1.528

0.397 (0.008)

1.498

% Reduction

8.0

2.5

0.5

0.3

Sen = 0.85

Spe = 0.85

Baseline

0.287 (0.007)

0.885 (0.005)

2.979

0.407 (0.007)

1.418

0.399 (0.007)

1.390

Reduced

0.265 (0.007)

0.883 (0.005)

3.332

0.405 (0.007)

1.528

0.397 (0.007)

1.498

% Reduction

8.0

2.2

0.5

0.3

Sen = 0.80

Spe = 0.80

Baseline

0.286 (0.007)

0.939 (0.004)

3.283

0.426 (0.008)

1.489

0.422 (0.008)

1.475

Reduced

0.265 (0.007)

0.938 (0.004)

3.540

0.424 (0.008)

1.600

0.421 (0.008)

1.589

% Reduction

8.0

1.2

4.7

0.2

Sen = 1.00

Spe = 1.00

Baseline

0.104 (0.005)

0.104 (0.005)

1.000

0.110 (0.005)

1.058

0.048 (0.003)

0.461

Reduced

0.084 (0.004)

0.084 (0.004)

1.000

0.103 (0.005)

1.220

0.039 (0.003)

0.464

% Reduction

19.2

19.2

6.3

18.7

Sen = 0.95

Spe = 0.95

Baseline

0.104 (0.005)

0.527 (0.008)

5.067

0.270 (0.007)

2.596

0.237 (0.007)

2.279

Reduced

0.084 (0.004)

0.518 (0.008)

6.167

0.267 (0.007)

3.179

0.233 (0.006)

2.774

% Reduction

19.2

1.7

1.1

1.7

Sen = 0.95

Spe = 0.90

Baseline

0.104 (0.005)

0.749 (0.007)

7.202

0.355 (0.007)

3.413

0.338 (0.007)

3.250

Reduced

0.084 (0.005)

0.745 (0.007)

8.869

0.353 (0.007)

4.202

0.335 (0.007)

3.988

% Reduction

19.2

0.5

0.6

0.8

Sen = 0.90

Spe = 0.90

Baseline

0.104 (0.004)

0.748 (0.007)

7.192

0.354 (0.008)

3.404

0.337 (0.008)

3.240

Reduced

0.084 (0.004)

0.743 (0.007)

8.845

0.353 (0.008)

4.202

0.335 (0.008)

3.988

% Reduction

19.2

0.7

0.3

0.6

Sen = 0.90

Spe = 0.85

Baseline

0.104 (0.005)

0.867 (0.006)

8.337

0.400 (0.008)

3.846

0.390 (0.008)

3.750

Reduced

0.084 (0.004)

0.865 (0.005)

10.298

0.399 (0.008)

4.750

0.390 (0.008)

4.643

% Reduction

19.2

0.3

0.2

0

Sen = 0.85

Spe = 0.85

Baseline

0.104 (0.005)

0.866 (0.005)

8.327

0.399 (0.007)

3.837

0.389 (0.007)

3.740

Reduced

0.084 (0.004)

0.864 (0.005)

10.286

0.398 (0.007)

4.738

0.388 (0.007)

4.619

% Reduction

19.2

0.2

0.2

0.2

Sen = 0.80

Spe = 0.80

Baseline

0.104 (0.005)

0.930 (0.004)

8.942

0.424 (0.008)

4.077

0.419 (0.008)

4.029

Reduced

0.084 (0.004)

0.929 (0.004)

11.060

0.423 (0.008)

5.036

0.418 (0.008)

4.976

% Reduction

19.2

0.1

0.2

0.2