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Table 1 Designated and estimated prevalence of the 14 high-risk virus types by Linear Array (LA)-only, Hybrid Capture (HC2)-only, and sequential testing strategies in the United States and Latin America

From: Comparison of DNA testing strategies in monitoring human papillomavirus infection prevalence through simulation

Genotyping assay performance Time Designated composite prevalence (SD) LA-only HC2-only Sequential test
Composite prevalence estimate (SD) Estimate-to-true ratio Composite prevalence estimate (SD) Estimate-to-true ratio Composite prevalence estimate (SD) Estimate-to-true ratio
United States
Sen = 1.00
Spe = 1.00
Baseline 0.287 (0.007) 0.287 (0.007) 1.000 0.180 (0.006) 0.628 0.129 (0.005) 0.446
Reduced 0.265 (0.007) 0.265 (0.007) 1.000 0.172 (0.006) 0.657 0.124 (0.005) 0.468
% Reduction 7.6 7.6   0.3   3.9  
Sen = 0.95
Spe = 0.95
Baseline 0.287 (0.007) 0.612 (0.008) 2.132 0.303 (0.007) 1.056 0.275 (0.007) 0.958
Reduced 0.265 (0.007) 0.602 (0.008) 2.272 0.299 (0.007) 1.128 0.271 (0.007) 1.023
% Reduction 7.6 1.6   1.3   1.5  
Sen = 0.95
Spe = 0.90
Baseline 0.287 (0.007) 0.792 (0.006) 2.760 0.371 (0.008) 1.293 0.356 (0.008) 1.240
Reduced 0.265 (0.007) 0.787 (0.007) 2.970 0.369 (0.008) 1.392 0.354 (0.008) 1.340
% Reduction 8.0 0.6   0.5   0.6  
Sen = 0.90
Spe = 0.90
Baseline 0.287 (0.007) 0.788 (0.006) 2.746 0.370 (0.007) 1.289 0.355 (0.007) 1.237
Reduced 0.265 (0.007) 0.783 (0.007) 2.955 0.368 (0.007) 1.389 0.352 (0.002) 1.328
% Reduction 7.7 0.6   0.5   0.8  
Sen = 0.90
Spe = 0.85
Baseline 0.287 (0.007) 0.887 (0.005) 3.091 0.407 (0.008) 1.418 0.399 (0.008) 1.390
Reduced 0.265 (0.007) 0.885 (0.005) 3.340 0.405 (0.008) 1.528 0.397 (0.008) 1.498
% Reduction 8.0 2.5   0.5   0.3  
Sen = 0.85
Spe = 0.85
Baseline 0.287 (0.007) 0.885 (0.005) 2.979 0.407 (0.007) 1.418 0.399 (0.007) 1.390
Reduced 0.265 (0.007) 0.883 (0.005) 3.332 0.405 (0.007) 1.528 0.397 (0.007) 1.498
% Reduction 8.0 2.2   0.5   0.3  
Sen = 0.80
Spe = 0.80
Baseline 0.286 (0.007) 0.939 (0.004) 3.283 0.426 (0.008) 1.489 0.422 (0.008) 1.475
Reduced 0.265 (0.007) 0.938 (0.004) 3.540 0.424 (0.008) 1.600 0.421 (0.008) 1.589
% Reduction 8.0 1.2   4.7   0.2  
Latin America
Sen = 1.00
Spe = 1.00
Baseline 0.104 (0.005) 0.104 (0.005) 1.000 0.110 (0.005) 1.058 0.048 (0.003) 0.461
Reduced 0.084 (0.004) 0.084 (0.004) 1.000 0.103 (0.005) 1.220 0.039 (0.003) 0.464
% Reduction 19.2 19.2   6.3   18.7  
Sen = 0.95
Spe = 0.95
Baseline 0.104 (0.005) 0.527 (0.008) 5.067 0.270 (0.007) 2.596 0.237 (0.007) 2.279
Reduced 0.084 (0.004) 0.518 (0.008) 6.167 0.267 (0.007) 3.179 0.233 (0.006) 2.774
% Reduction 19.2 1.7   1.1   1.7  
Sen = 0.95
Spe = 0.90
Baseline 0.104 (0.005) 0.749 (0.007) 7.202 0.355 (0.007) 3.413 0.338 (0.007) 3.250
Reduced 0.084 (0.005) 0.745 (0.007) 8.869 0.353 (0.007) 4.202 0.335 (0.007) 3.988
% Reduction 19.2 0.5   0.6   0.8  
Sen = 0.90
Spe = 0.90
Baseline 0.104 (0.004) 0.748 (0.007) 7.192 0.354 (0.008) 3.404 0.337 (0.008) 3.240
Reduced 0.084 (0.004) 0.743 (0.007) 8.845 0.353 (0.008) 4.202 0.335 (0.008) 3.988
% Reduction 19.2 0.7   0.3   0.6  
Sen = 0.90
Spe = 0.85
Baseline 0.104 (0.005) 0.867 (0.006) 8.337 0.400 (0.008) 3.846 0.390 (0.008) 3.750
Reduced 0.084 (0.004) 0.865 (0.005) 10.298 0.399 (0.008) 4.750 0.390 (0.008) 4.643
% Reduction 19.2 0.3   0.2   0  
Sen = 0.85
Spe = 0.85
Baseline 0.104 (0.005) 0.866 (0.005) 8.327 0.399 (0.007) 3.837 0.389 (0.007) 3.740
Reduced 0.084 (0.004) 0.864 (0.005) 10.286 0.398 (0.007) 4.738 0.388 (0.007) 4.619
% Reduction 19.2 0.2   0.2   0.2  
Sen = 0.80
Spe = 0.80
Baseline 0.104 (0.005) 0.930 (0.004) 8.942 0.424 (0.008) 4.077 0.419 (0.008) 4.029
Reduced 0.084 (0.004) 0.929 (0.004) 11.060 0.423 (0.008) 5.036 0.418 (0.008) 4.976
% Reduction 19.2 0.1   0.2   0.2  
  1. Type-specific prevalence at baseline, in the United States: HPV16 = 0.047; HPV18 = 0.019; HPV31 = 0.022; HPV33 = 0.015; HPV35 = 0.013; HPV39 = 0.022; HPV45 = 0.020; HPV51 = 0.041; HPV52 = 0.036; HPV56 = 0.023; HPV58 = 0.014; HPV59 = 0.030; HPV66 = 0.034; and HPV68 = 0.016; in Latin America: HPV16 = 0.033; HPV18 = 0.012; HPV31 = 0.012; HPV33 = 0.008; HPV35 = 0.007; HPV39 = 0.004; HPV45 = 0.007; HPV51 = 0.005; HPV52 = 0.007; HPV56 = 0.004; HPV58 = 0.001; HPV59 = 0.004; HPV66 = 0.004; and HPV68 = 0.004
  2. Reduced: HPV16 and HPV18 are reduced by 50 %
  3. Abbreviations: SD standard deviation, Sen sensitivity, Spe specificity