Table 3 Univariable and multivariable analysis of risk factors for virological failure

PDR resistant vs no PDR/susceptible

1.78

(0.89–3.54)

0.101

1.42

(0.62–3.24)

0.400

Sex (male vs female)

1.06

(0.71–1.60)

0.770

1.45

(0.91–2.31)

0.117

Age (per additional year)

0.89

(0.84–0.93)

0.000

0.88

(0.82–0.95)

0.0005

Origin (ref Europe)

0.029

0.720

 Africa

0.40

(0.20–0.78)

0.008

1.14

(0.49–2.62)

0.759

 Asia

0.73

(0.45–1.18)

0.197

1.02

(0.464–2.25)

0.960

 Other/unknown

1.10

(0.58–2.09)

0.764

0.65

(0.28–1.50)

0.313

Previous AIDS diagnosis (yes vs no)

1.18

(0.73–1.91)

0.495

1.00

(0.56–1.76)

0.986

Pretreatment CD4 count (per 100 cells/mm³)

1.01

(0.98–1.04)

0.510

0.96

(0.92–1.00)

0.048

Pretreatment viral load (per 1 log₁₀ copies/mL increase)

1.16

(0.90–1.50)

0.254

0.99

(0.76–1.28)

0.987

Subtype (non B vs B)

0.85

(0.48–1.50)

0.569

0.70

(0.34–1.45)

0.335

Year of treatment start (ref: 2007–2008)

0.018

0.818

 1998–1999

3.14

(1.22–8.07)

0.018

1.11

(0.25–4.95)

0.891

 2000–2002

2.01

(0.71–5.70)

0.190

1.89

(0.48–7.40)

0.361

 2003–2004

1.97

(0.75–5.21)

0.170

1.29

(0.34–4.96)

0.710

 2005–2006

1.36

(0.52–3.60)

0.532

1.27

(0.34–4.79)

0.7230

Antiretroviral drug combination (ref: NNRTI plus ≥ 2NRTIs)

0.0002

0.007

 Unboosted PI plus ≥ 2NRTIs

19.5

(2.68; 1.73)

<0.001

3.65

(1.65; 8.05)

0.001

 Boosted PI plus ≥ 2NRTIs

1.26

(0.56; 2.83)

0.572

1.79

(0.76; 4.57)

0.222

 Other

1.73

(0.62; 4.85)

0.300

2.65

(0.90; 7.81)

0.077