Table 4 Accelerated failure time models of factors associated with time to viral rebound among MSM who suppressed
| Â | Unadjusted hazard ratio (95Â % confidence interval) | P-value | Adjusted hazard ratio (95Â % confidence interval) | P-value |
|---|---|---|---|---|
Province | ||||
 British Columbia | 1.00 | <0.001 | 1.00 | <0.001 |
 Ontario | 0.54 (0.42–0.71) | 0.50 (0.38–0.67) | ||
 Quebec | 0.48 (0.36–0.64) | 0.51 (0.38–0.69) | ||
Baseline age (per 10 year increment) | 0.75 (0.66–0.86) | <0.001 | 0.70 (0.62–0.80) | <0.001 |
Ethnicity | ||||
 Caucasian | 1.00 | 0.008 |  |  |
 Black | 1.35 (0.60–3.06) | |||
 Aboriginal | 1.67 (0.93–3.00) | |||
 Other | 0.98 (0.70–1.38) | |||
 Unknown | 0.67 (0.51–0.89) | |||
History of IDU | ||||
 No | 1.00 | <0.001 | 1.00 | <0.001 |
 Yes | 2.67 (1.96–3.64) | 2.52 (1.82–3.50) | ||
 Unknown | 2.02 (1.04–3.93) | 2.18 (1.09–4.36) | ||
Era of cART initiation | ||||
 2000–03 | 1.00 | <0.001 | 1.00 | <0.001 |
 2004–07 | 0.71 (0.56–0.92) | 0.69 (0.53–0.91) | ||
 2008–12 | 0.49 (0.35–0.69) | 0.43 (0.30–0.61) | ||
Initial 3rd ARV class | ||||
 NNRTI | 1.00 | 0.082 | 1.00 | 0.057 |
 Unboosted PI | 1.60 (0.99–2.59) | 1.48 (0.90–2.42) | ||
 Boosted PI | 1.16 (0.91–1.49) | 1.13 (0.86–1.48) | ||
 Other | 1.53 (1.01–2.31) | 1.70 (1.12–2.59) | ||
Baseline AIDS-defining illness | ||||
 No | 1.00 |  |  |  |
 Yes | 0.99 (0.73–1.34) |  | ||
 Unknown | 1.00 (0.58–1.72) | 0.999 | ||
Baseline viral load (per log10 copies/mL) | 1.11 (0.85–1.45) | 0.454 |  |  |
Baseline CD4 count (per 100 cells/mm3) | 1.05 (0.97–1.13) | 0.227 | 1.13 (1.05–1.22) | 0.001 |
Time to suppression (months) | 1.04 (0.99–1.09) | 0.118 | 1.04 (0.99–1.09) | 0.144 |