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Table 4 Accelerated failure time models of factors associated with time to viral rebound among MSM who suppressed

From: Predictors of viral suppression and rebound among HIV-positive men who have sex with men in a large multi-site Canadian cohort

  Unadjusted hazard ratio (95 % confidence interval) P-value Adjusted hazard ratio (95 % confidence interval) P-value
Province
 British Columbia 1.00 <0.001 1.00 <0.001
 Ontario 0.54 (0.42–0.71) 0.50 (0.38–0.67)
 Quebec 0.48 (0.36–0.64) 0.51 (0.38–0.69)
Baseline age (per 10 year increment) 0.75 (0.66–0.86) <0.001 0.70 (0.62–0.80) <0.001
Ethnicity
 Caucasian 1.00 0.008   
 Black 1.35 (0.60–3.06)
 Aboriginal 1.67 (0.93–3.00)
 Other 0.98 (0.70–1.38)
 Unknown 0.67 (0.51–0.89)
History of IDU
 No 1.00 <0.001 1.00 <0.001
 Yes 2.67 (1.96–3.64) 2.52 (1.82–3.50)
 Unknown 2.02 (1.04–3.93) 2.18 (1.09–4.36)
Era of cART initiation
 2000–03 1.00 <0.001 1.00 <0.001
 2004–07 0.71 (0.56–0.92) 0.69 (0.53–0.91)
 2008–12 0.49 (0.35–0.69) 0.43 (0.30–0.61)
Initial 3rd ARV class
 NNRTI 1.00 0.082 1.00 0.057
 Unboosted PI 1.60 (0.99–2.59) 1.48 (0.90–2.42)
 Boosted PI 1.16 (0.91–1.49) 1.13 (0.86–1.48)
 Other 1.53 (1.01–2.31) 1.70 (1.12–2.59)
Baseline AIDS-defining illness
 No 1.00    
 Yes 0.99 (0.73–1.34)  
 Unknown 1.00 (0.58–1.72) 0.999
Baseline viral load (per log10 copies/mL) 1.11 (0.85–1.45) 0.454   
Baseline CD4 count (per 100 cells/mm3) 1.05 (0.97–1.13) 0.227 1.13 (1.05–1.22) 0.001
Time to suppression (months) 1.04 (0.99–1.09) 0.118 1.04 (0.99–1.09) 0.144