Table 3 GNLY polymorphisms and other factors associated with serum GNLY concentrations or GNLY mRNA expression levels in blood in univariate and multivariate regression models (n = 109)
Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
Coefficient | 95 % CI | P value | Coefficient | 95 % CI | P value | |
a) Polymorphism of rs11127 SNP in exon 4 of the GNLY was inversely associated with serum GNLY concentrations (log-transformed values) | ||||||
Age (increased by one year) | 0.00 | −0.01 to 0.01 | 0.985 | 0.00 | −0.01 to 0.01 | 0.666 |
Gender (female vs. male) | 0.04 | −0.13 to 0.22 | 0.628 | 0.08 | −0.09 to 0.25 | 0.359 |
Genotype (increased by one C allele) | −0.18 | −0.29 to −0.07 | 0.001 | −0.19 | −0.30 to −0.08 | 0.001 |
b) Polymorphism of rs11127 SNP in exon 4 of the GNLY was not associated with GNLY mRNA expression levels (log-transformed values) in blood | ||||||
Age (increased by one year) | 0.00 | −0.01 to 0.01 | 0.870 | 0.00 | −0.01 to 0.01 | 0.883 |
Gender (female vs. male) | −0.33 | −0.61 to −0.05 | 0.021 | −0.34 | −0.62 to −0.06 | 0.019 |
Genotype (increased by one C allele) | 0.03 | −0.15 to 0.21 | 0.725 | 0.06 | −0.12 to 0.24 | 0.532 |