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Table 3 Mutations in the rpoB, katG, pncA and embB genes with the associated MICs and genotypes of the MDR isolates

From: Mechanisms of first-line antimicrobial resistance in multi-drug and extensively drug resistant strains of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa

Isolate Genotype MIC (mg/L) Mutation Profile
aAssociated amino acid substitutions
RIF INH EMB rpoB katG pncA embB
MODS11 KZN 8 8 8 T1355C G944C ΔC A916G
MODS688 KZN 128 8 8 C1349T
T1690C
G944C T416G A916G
TF44949 F28 32 16 8 C1349T G944C - A916G
TF3251 KZN 128 16 16 G1303T
C1360A
G944C - A916G
TF78838 F28 128 16 8 C1349T G944C T100G A916G
TF2063 F28 128 16 16 C1349T G944C T100G A916G
TF3203 F28 128 16 16 C1349T G944C T100G A916G
TF1951 F28V 128 16 16 A1334T
G1473C
G944C - A916G
TF64747 KZN 128 16 8 C1349T
T1690C
G944C T416G A916G
TF2889 F28 64 16 8 C1349T
T1355C
G944C - C1489A
TF2040 F28 128 16 16 C1349T G944C T100G C1489A
MODS682 F28 128 16 16 - G944C - -
TF36480 KZN 128 16 8 - G944C T100G -
TF2034 Unique 64 16 16 C1349T
T1355C
G944C
A1343C
- -
TF2153 F28 128 16 16 - G944C T100G -
  1. a rpoB: C1303T = D435Y; A1334T = H445L; C1349T = S450L; T1355C = L452P; C1360A = P454T; G1473C = I491M; T1690C = Y564H
  2. katG: G944C = S315T
  3. pncA: ΔC = Insertion of cytosine at position 457; T100G = Y34D; T416G = L139G
  4. embB: A916G = M306V; C1489A = Q506K