Table 3 Mutations in the rpoB, katG, pncA and embB genes with the associated MICs and genotypes of the MDR isolates
Isolate | Genotype | MIC (mg/L) | Mutation Profile aAssociated amino acid substitutions | |||||
|---|---|---|---|---|---|---|---|---|
RIF | INH | EMB | rpoB | katG | pncA | embB | ||
MODS11 | KZN | 8 | 8 | 8 | T1355C | G944C | ΔC | A916G |
MODS688 | KZN | 128 | 8 | 8 | C1349T T1690C | G944C | T416G | A916G |
TF44949 | F28 | 32 | 16 | 8 | C1349T | G944C | - | A916G |
TF3251 | KZN | 128 | 16 | 16 | G1303T C1360A | G944C | - | A916G |
TF78838 | F28 | 128 | 16 | 8 | C1349T | G944C | T100G | A916G |
TF2063 | F28 | 128 | 16 | 16 | C1349T | G944C | T100G | A916G |
TF3203 | F28 | 128 | 16 | 16 | C1349T | G944C | T100G | A916G |
TF1951 | F28V | 128 | 16 | 16 | A1334T G1473C | G944C | - | A916G |
TF64747 | KZN | 128 | 16 | 8 | C1349T T1690C | G944C | T416G | A916G |
TF2889 | F28 | 64 | 16 | 8 | C1349T T1355C | G944C | - | C1489A |
TF2040 | F28 | 128 | 16 | 16 | C1349T | G944C | T100G | C1489A |
MODS682 | F28 | 128 | 16 | 16 | - | G944C | - | - |
TF36480 | KZN | 128 | 16 | 8 | - | G944C | T100G | - |
TF2034 | Unique | 64 | 16 | 16 | C1349T T1355C | G944C A1343C | - | - |
TF2153 | F28 | 128 | 16 | 16 | - | G944C | T100G | - |