Implementation of a pragmatic, stepped-wedge cluster randomized trial to evaluate impact of Botswana’s Xpert MTB/RIF diagnostic algorithm on TB diagnostic sensitivity and early antiretroviral therapy mortality

Table 2 Selected study sites for the Xpert package rollout evaluation using a stepped-wedge design (XPRES)

District	Fixed consortiums	Clinic names	Pre-study estimates of no. new ART patients/month	Xpert location
Ngami (Maun)	fixed triplet	Letsholathebe II Memorial Hospital	36	1 × Lab Xpert
Ngami (Maun)		Boseja Clinic	28
Ngami (Maun)		Maun Clinic	28
Gaborone	fixed pair	Brodhurst Traditional Clinic	35	1 × Lab Xpert
Gaborone	fixed pair	Bontleng Clinic	45	1 × Lab Xpert
Francistown	fixed pair	Botswelelo Clinic	22	1 × Lab Xpert
Francistown	fixed pair	Area W Clinic	22	1 × Lab Xpert
Francistown	single facility	Nyangabgwe Referral Hospital	18	1 × Lab Xpert
Kweneng East-Molepolole	fixed quadruplet	Borakalalo Clinic	9	1 × POC Xpert
Kweneng East-Molepolole		Kgosing Clinic	8
Kweneng East-Molepolole		Molepolole Central Clinic	8
Kweneng East-Molepolole		Phuth-kobo Clinic	8
Kweneng East-Mogoditsane	single facility	Nkoyaphiri Clinic	46	1 × POC Xpert
Palapye	fixed pair	Ext 3 Clinic	20	1 × POC Xpert
Palapye	fixed pair	Lotsane Clinic	20	1 × POC Xpert
Bobirwa	single facility	Bobonong Primary Hospital	38	1 × Lab Xpert
Kanye	single facility	SDA Hospital	22	1 × Lab Xpert
Gantsi	single facility	Gantsi Clinic	unknown*	1 × Lab Xpert
Kgatleng	single facility	Deborah Memorial Hospital	26	1 × Lab Xpert
Lobatse	single facility	Athlon Clinic	18	1 × Lab Xpert
Serowe District	fixed pair	Kadimo Clinic	12	1 × POC Xpert
Serowe District	fixed pair	Serowe Clinic	12	1 × POC Xpert
Total (22 clinics)			479	13
Average per clinic			23

Abbreviations: POC point of care, Xpert Xpert MTB/RIF, lab laboratory, ART antiretroviral therapy
*Routine monitoring data on rate of enrollment of antiretroviral therapy patients was not available at the time of study initiation for this clinic

ISSN: 1471-2334