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Table 1 Demographic and clinical characteristics of the study cohort

From: Carbapenem-Resistant Klebsiella pneumoniae influences the outcome of early infections in liver transplant recipients

Characteristics All patients n = 88, (%) 180-day outcome p value
Survival
n = 61 (%)
Death
n = 27 (%)
Age (years, ranges) 53 (34–67) 52 (34–66) 54 (37–67) 0.803
Gender Male 70 (80) 51 (84) 19 (70) 0.257
MELD score ≥25a 23 (26) 14 (23) 9 (33) 0.448
Child-Pugh stage C 42 (48) 27 (44) 15 (56) 0.436
Pre-LT hospitalizationb 18 (20) 10 (16) 8 (30) 0.257
Previous Abdominal Surgery 7 (8) 5 (8) 2 (7) 0.900
Indication for LT - Viralc 58 (66) 40 (66) 18 (67) 1.000
HCV positivity 49 (56) 35 (57) 14 (52) 0.804
HBs-Ag positivity 13 (15) 8 (13) 5 (18) 0.739
HIV positivity 9 (10) 5 (8) 4 (15) 0.448
Presence of HCCd 30 (34) 22 (36) 8 (30) 0.731
Type of anastomosis
Roux-en-y 10 (11) 6 (10) 4 (15) 0.488
Termino-terminal 78 (89) 55 (90) 23 (85)  
RBC units ≥ 5e 72 (82) 48 (79) 24 (89) 0.398
Plasma units ≥ 10 39 (44) 26 (43) 13 (48) 0.804
RRTf 20 (23) 5 (8) 15 (56) <0.0001
Rejection 41 (47) 30 (49) 11 (41) 0.617
Diabetes 14 (16) 12 (20) 2 (7) 0.216
Multisite infectionsg 34 (39) 14 (23) 20 (74) <0.0001
Pneumonia 43 (49) 22 (36) 21 (78) 0.001
SSIsh 40 (45) 25 (41) 15 (56) 0.301
BSIsi 31 (35) 14 (23) 17 (63) 0.001
UTIsj 30 (34) 20 (33) 10 (37) 0.885
Gram-positive bacteria 45 (51) 29 (48) 16 (59) 0.434
Gram-negative bacteria 64 (73) 40 (66) 24 (89) 0.045
Polymicrobial infectionsk 24 (27) 11 (18) 13 (48) 0.008
Fungi 9 (10) 5 (8) 4 (15) 0.448
Mixed infectionsl 6 (7) 2 (3) 4 (15) 0.069
Overall resistant infectionsm 78 (89) 52 (85) 26 (96) 0.253
CRKP infectionsn 13 (15) 4 (7) 9 (33) 0.002
CMV infection 29 (33) 14 (23) 15 (56) 0.006
  1. aMELD: Model for End-Stage Liver Disease
  2. bPre-LT hospitalization: included any hospitalization within one month before LT
  3. cIndication for LT included: viral [n = 58], alcoholic [n = 11], cryptogenetic [n = 7], cholestatic [n = 6], and other [n = 6] causes
  4. dHCC: Hepato Cellular Carcinoma
  5. eRBC: red blood cell units
  6. fRRT: renal replacement therapy included: dialysis, continuous veno-venous haemo(dia)filtration and plasmapheresis
  7. gMultisite infections: ≥ 2 sites (i.e.: blood and urine; blood and surgical sites etc.) were contemporarily involved
  8. hSSIs: surgical sites infections
  9. iBSIs: blood stream infections
  10. jUTIs: urinary tract infections
  11. kPolymicrobial infections: infections caused by both Gram-negative and Gram-positive bacteria
  12. lMixed infections: infections caused by both bacterial and fungal pathogens
  13. mOverall resistant infections: infections caused by a bacterial pathogen showing any resistant pattern (see for details Table 3)
  14. nCRKP infections: infections caused by carbapenem-resistant Klebsiella pneumoniae strains