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Table 2 Clinical features, treatment and outcome

From: Temporal trends of β-haemolytic streptococcal osteoarticular infections in western Norway

  GAS n = 24 GBS n = 45 GCGS n = 40 a GAS vs GBS GAS vs GCGS GBS vs GCGS
Symptoms        Adjusted p-values *
 Duration days (IQR) 1 (1–5) 5 (2–13) 3 (1–9) 0.036 1.0 0.72
 Fever 21 88 % 30 67 % 23 58 % 0.63 0.09 1.0
Severity
 SIRS 18 75 % 23 51 % 24 60 % 0.48 1.0 1.0
 STSS 2 8 % 0 0 % 1 3 % 0.66 1.0 1.0
Surgical treatment
 NJI 14   12   21     
  Irrigation 8 57 % 3 25 % 13 62 %    
  Revision 2 14 % 2 17 % 4 19 %    
  Amputation 2 14 % 0 0 % 2 10 %    
  Antibiotics alone 2 14 % 7 58 % 2 10 %    
 PJI 5   22   15     
  Revision 5 100 % 9 41 % 7 47 %    
  1-stage 0 0 % 2 9 % 1 7 %    
  2-stage 0 0 % 5 23 % 3 20 %    
  Amputation 0 0 % 1 5 % 1 7 %    
  Antibiotics alone 0 0 % 5 23 % 3 20 %    
Treatment duration
 NJI days (IQR) 42 (32–52) 38 (28–76) 42 (34–56)    
 PJI days (IQR) 90 (14–180) 137 (76–361) 91 (42–130)    
 AOM days (IQR) 56 (42–56) 60 (50–116) 63 (51–81)    
Outcome
 Death <30 day 2 8 % 1 2 % 1 3 % 1.0 1.0 1.0
 Sequelae 10 42 % 15 33 % 15 38 % 1.0 1.0 1.0
 Amputation 2 8 % 2 4 % 3 8 % 1.0 1.0 1.0
 Relapse 3 13 % 9 20 % 4 10 % 1.0 1.0 1.0
 Chronic suppression 0 0 % 5 11 % 1 3 % 0.8 1.0 1.0
  1. All data are presented as n (%), except “Duration of symptoms” and “Treatment duration” presented as median number of days (Inner Quartile Range (IQR)). Significant values are highlighted in bold
  2. Abbreviations: GAS group A streptococci, GBS group B streptococci, GCGS group C and G streptococci, SIRS systemic inflammatory response syndrome, STSS streptococcal toxic shock syndrome, NJI native joint infection, PJI prosthetic joint infection, AOM acute osteomyelitis
  3. * The p-values are adjusted for multiple comparisons ad modum Holm-Bonferroni
  4. a Two GCGS cases did not provide informed consent, and were excluded from the analyses