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Table 2 Clinical features, treatment and outcome

From: Temporal trends of β-haemolytic streptococcal osteoarticular infections in western Norway

 

GAS n = 24

GBS n = 45

GCGS n = 40 a

GAS vs GBS

GAS vs GCGS

GBS vs GCGS

Symptoms

      

Adjusted p-values *

 Duration days (IQR)

1

(1–5)

5

(2–13)

3

(1–9)

0.036

1.0

0.72

 Fever

21

88 %

30

67 %

23

58 %

0.63

0.09

1.0

Severity

 SIRS

18

75 %

23

51 %

24

60 %

0.48

1.0

1.0

 STSS

2

8 %

0

0 %

1

3 %

0.66

1.0

1.0

Surgical treatment

 NJI

14

 

12

 

21

    

  Irrigation

8

57 %

3

25 %

13

62 %

   

  Revision

2

14 %

2

17 %

4

19 %

   

  Amputation

2

14 %

0

0 %

2

10 %

   

  Antibiotics alone

2

14 %

7

58 %

2

10 %

   

 PJI

5

 

22

 

15

    

  Revision

5

100 %

9

41 %

7

47 %

   

  1-stage

0

0 %

2

9 %

1

7 %

   

  2-stage

0

0 %

5

23 %

3

20 %

   

  Amputation

0

0 %

1

5 %

1

7 %

   

  Antibiotics alone

0

0 %

5

23 %

3

20 %

   

Treatment duration

 NJI days (IQR)

42

(32–52)

38

(28–76)

42

(34–56)

   

 PJI days (IQR)

90

(14–180)

137

(76–361)

91

(42–130)

   

 AOM days (IQR)

56

(42–56)

60

(50–116)

63

(51–81)

   

Outcome

 Death <30 day

2

8 %

1

2 %

1

3 %

1.0

1.0

1.0

 Sequelae

10

42 %

15

33 %

15

38 %

1.0

1.0

1.0

 Amputation

2

8 %

2

4 %

3

8 %

1.0

1.0

1.0

 Relapse

3

13 %

9

20 %

4

10 %

1.0

1.0

1.0

 Chronic suppression

0

0 %

5

11 %

1

3 %

0.8

1.0

1.0

  1. All data are presented as n (%), except “Duration of symptoms” and “Treatment duration” presented as median number of days (Inner Quartile Range (IQR)). Significant values are highlighted in bold
  2. Abbreviations: GAS group A streptococci, GBS group B streptococci, GCGS group C and G streptococci, SIRS systemic inflammatory response syndrome, STSS streptococcal toxic shock syndrome, NJI native joint infection, PJI prosthetic joint infection, AOM acute osteomyelitis
  3. * The p-values are adjusted for multiple comparisons ad modum Holm-Bonferroni
  4. a Two GCGS cases did not provide informed consent, and were excluded from the analyses