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Table 3 Liver enzymes and function

From: Micafungin versus anidulafungin in critically ill patients with invasive candidiasis: a retrospective study

A Anidulafungin Micafungin P
(n = 30) (n = 33)
 Liver failurea 9 (30) 2 (6) 0.01
 Increased serum AST (U/L) after starta 13 (43) 12 (36) 0.58
 Increased serum ALT (U/L) after starta 13 (43) 10 (30) 0.29
 Serum AST (U/L) at start 95 (282) 55 (76) 0.09
 Serum ALT (U/L) at start 56 (125) 39 (59) 0.13
 Serum AST (U/L) at stop 115 (1011) 52 (108) 0.17
 Serum ALT (U/L) at stop 75 (312) 45 (68) 0.14
 Serum AST (U/L) peak 285 (228) 116 (181) 0.11
 Serum ALT (U/L) peak 150 (404) 70 (126) 0.15
 Serum bilirubin (μmol/L) peak 71 (192) 15 (29) 0.05
 Prothrombin Time (sec) peak 18.3 (15.4) 17.8 (8.0) 0.27
B Anidulafungin Micafungin P
(n = 21) (n = 31)
 Increased serum AST (U/L) after starta 8 (38) 11 (35) 0.85
 Increased serum ALT (U/L) after starta 7 (33) 9 (29) 0.74
 Serum AST (U/L) at start 61 (98) 55 (73) 0.82
 Serum ALT (U/L) at start 43 (75) 39 (54) 0.89
 Serum AST (U/L) at stop 44 (141) 49 (79) 0.98
 Serum ALT (U/L) at stop 41 (83) 45 (54) 0.99
 Serum AST (U/L) peak 129 (267) 113 (158) 0.88
 Serum ALT (U/L) peak 69 (209) 61 (119) 0.95
 Serum bilirubin (μmol/L) peak 20 (105) 14 (27) 0.74
 Prothrombin Time (sec) peak 16.6 (7.5) 17.8 (5.3) 0.68
  1. Numbers (percentage) aor median (interquartile range). Liver enzymes and function in all patients who were treated with anidulafungin and micafungin (A) and in patients without liver failure (B)
  2. Abbreviations: ALT alanine transaminase, AST aspartate transaminase