Table 3 Liver enzymes and function

 Liver failure^a

9 (30)

2 (6)

0.01

 Increased serum AST (U/L) after start^a

13 (43)

12 (36)

0.58

 Increased serum ALT (U/L) after start^a

13 (43)

10 (30)

0.29

 Serum AST (U/L) at start

95 (282)

55 (76)

0.09

 Serum ALT (U/L) at start

56 (125)

39 (59)

0.13

 Serum AST (U/L) at stop

115 (1011)

52 (108)

0.17

 Serum ALT (U/L) at stop

75 (312)

45 (68)

0.14

 Serum AST (U/L) peak

285 (228)

116 (181)

0.11

 Serum ALT (U/L) peak

150 (404)

70 (126)

0.15

 Serum bilirubin (μmol/L) peak

71 (192)

15 (29)

0.05

 Prothrombin Time (sec) peak

18.3 (15.4)

17.8 (8.0)

0.27

B

Anidulafungin

Micafungin

P

(n = 21)

(n = 31)

 Increased serum AST (U/L) after start^a

8 (38)

11 (35)

0.85

 Increased serum ALT (U/L) after start^a

7 (33)

9 (29)

0.74

 Serum AST (U/L) at start

61 (98)

55 (73)

0.82

 Serum ALT (U/L) at start

43 (75)

39 (54)

0.89

 Serum AST (U/L) at stop

44 (141)

49 (79)

0.98

 Serum ALT (U/L) at stop

41 (83)

45 (54)

0.99

 Serum AST (U/L) peak

129 (267)

113 (158)

0.88

 Serum ALT (U/L) peak

69 (209)

61 (119)

0.95

 Serum bilirubin (μmol/L) peak

20 (105)

14 (27)

0.74

 Prothrombin Time (sec) peak

16.6 (7.5)

17.8 (5.3)

0.68