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Table 2 Classification of CDI Cases by Setting of Acquisition

From: Cost of hospital management of Clostridium difficile infection in United States—a meta-analysis and modelling study

Case definition Criteria for classification
CO-CDI - Discharge code ICD-9-CM 008.45 as Primary diagnosis
HO-CDI - Discharge code ICD-9-CM 008.45 as secondary diagnosis, without a primary diagnosis of a CDI-related symptom (e.g. diarrhea)
- Study population ≥ 48 h of hospitalization
- Symptom onset and/or positive laboratory assay at least ≥ 48 h hospitalization
Both CDI - No distinction of settings of acquisition
- Discharge code ICD-9-CM 008.45 in any position
  1. Abbreviations: CO-CDI community-onset CDI, HO-CDI hospital-onset CDI, ICD-9-CM The International Classification of Diseases, Ninth Revision, Clinical Modification