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Table 1 Epidemiological and clinical characteristics of 40 ICU patients with fungemia caused by fluconazole-resistant C. parapsilosis (FRCP) and fluconazole-susceptible Candida species (FSC)

From: Outbreak of candidemia caused by fluconazole resistant Candida parapsilosis strains in an intensive care unit

  FRCP (N = 21) FSCa (N = 19) P value
Age (years) - median (range) 70 (23–91) 76 (35–90) 0.311
Gender female - n (%) 7 (33.3) 8 (42.1) 0.567
Time to candidemia – median/range 22 (0–83) 25 (7–134) 0.185
Apache II score – median/range 14 (3–29) 16 (3–30) 0.138
Death up to 30 days after candidemia (%) 9 (42.9) 9 (47.4) 0.78
Comorbidities - n (%)
 Cancer 5 (23.8) 2 (10.5) 0.270
 Pulmonary disease 9 (42.9) 11 (57.9) 0.342
 Cardiac disease 6 (28.6) 3 (15.8) 0.557
 Diabetes mellitusb 11 (52.4) 2 (10.5) 0.013
 Renal failure 4 (19.0) 3 (15.8) 1.000
Previous exposure to medical procedures and medicines - n (%)
 Short-term catheter 21 (100.0) 17 (89.5) 0.424
 Catheter tip positive 4 (19.0) 3 (15.8) 1.000
 Previous hemodialysis 3 (14.3) 1 (5.3) 0.673
 Prior surgery 12 (61.9) 10 (52.6) 0.775
 Mechanical ventilation 15 (71.4) 14 (73.7) 0.873
 Parenteral nutrition 7 (33.3) 1 (5.3) 0.059
 Previous Hospitalization 4 (19) 8 (42.1) 0.112
 Antibiotics 10 (47.6) 8 (42.1) 0.726
 Steroids 8 (38.1) 7 (36.8) 0.942
 Any antifungal drug 7 (33.3) 3 (15.8) 0.361
 Fluconazole 4 (19.0) 3 (15.8) 1.000
  1. aall Candida strains considered susceptible to fluconazole by the Vitek 2 system. bvariable identified as independent factor associated with infection by FRCP