|  | Cumulative exposure | Recent exposure | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | N | cIRR | 95 % CI | P | aIRR | 95 % CI | P | cIRR | 95 % CI | P | aIRR | 95 % CI | P |
ART | 109 | 0.85 | 0.81–0.89 | <0.001 | 0.79 | 0.75–0.83 | <0.001 | – | – | – | – | – | – |
NRTI | 109 | 0.85 | 0.81–0.89 | <0.001 | 0.79 | 0.75–0.83 | <0.001 | – | – | – | – | – | – |
Lamivudine | 105 | 0.80 | 0.75–0.84 | <0.001 | 0.76 | 0.72–0.81 | <0.001 | 0.56 | 0.30–1.05 | 0.069 | 0.71 | 0.37–1.36 | 0.31 |
Zidovudine | 93 | 0.86 | 0.81–0.91 | <0.001 | 0.83 | 0.78–0.89 | <0.001 | 1.27 | 0.86–1.89 | 0.23 | 1.34 | 0.90–2.00 | 0.15 |
Tenofovir | 39 | 0.64 | 0.55–0.75 | <0.001 | 0.60 | 0.51–0.71 | <0.001 | 0.42 | 0.28–0.64 | <0.001 | 0.37 | 0.24–0.56 | <0.001 |
Stavudine | 56 | 0.97 | 0.90–1.05 | 0.50 | 0.96 | 0.88–1.04 | 0.30 | 6.13 | 3.91–9.60 | <0.001 | 5.28 | 3.18–8.75 | <0.001 |
Didanosine | 51 | 0.95 | 0.87–1.04 | 0.29 | 0.91 | 0.82–1.02 | 0.10 | 1.47 | 0.68–3.17 | 0.32 | 1.50 | 0.68–3.27 | 0.32 |
Emtricitabine | 5 | 0.78 | 0.49–1.25 | 0.30 | 0.83 | 0.51–1.36 | 0.46 | 2.29 | 0.73–7.23 | 0.16 | 2.61 | 0.81–8.43 | 0.11 |
Abacavir | 6 | 0.70 | 0.43–1.14 | 0.15 | 0.63 | 0.36–1.11 | 0.11 | 0.97 | 0.24–3.94 | 0.97 | 0.70 | 0.17–2.86 | 0.62 |
Zalcitabine | 10 | 1.01 | 0.66–1.55 | 0.96 | 0.90 | 0.57–1.41 | 0.64 | – | – | – | – | – | – |
NNRTI | 79 | 0.76 | 0.69–0.83 | <0.001 | 0.77 | 0.70–0.85 | <0.001 | 1.05 | 0.72–1.55 | 0.79 | 1.42 | 0.94–2.13 | 0.097 |
Efavirenz | 67 | 0.75 | 0.67–0.84 | <0.001 | 0.78 | 0.69–0.87 | <0.001 | 0.90 | 0.60–1.34 | 0.59 | 1.25 | 0.81–1.93 | 0.31 |
Nevirapine | 31 | 0.92 | 0.81–1.05 | 0.24 | 0.91 | 0.78–1.05 | 0.20 | 2.46 | 1.20–5.06 | 0.014 | 3.07 | 1.44–6.53 | 0.004 |
PI | 79 | 0.92 | 0.88–0.96 | 0.001 | 0.88 | 0.83–0.93 | <0.001 | 1.20 | 0.80–1.81 | 0.37 | 0.79 | 0.50–1.23 | 0.29 |
PI (without high dose RTV) | 78 | 0.92 | 0.87–0.96 | <0.001 | 0.87 | 0.83–0.92 | <0.001 | 1.16 | 0.77–1.73 | 0.48 | 0.75 | 0.48–1.17 | 0.20 |
Ritonavir | 35 | 0.91 | 0.78–1.05 | 0.20 | 0.84 | 0.71–1.01 | 0.061 | 4.05 | 2.05–8.03 | <0.001 | 2.67 | 1.30–5.47 | 0.007 |
Lopinavir/ Ritonavir | 41 | 0.86 | 0.76–0.96 | 0.009 | 0.81 | 0.71–0.92 | 0.001 | 1.20 | 0.79–1.84 | 0.40 | 0.90 | 0.58–1.39 | 0.64 |
Atazanavir + Ritonavir | 13 | 0.60 | 0.45–0.79 | <0.001 | 0.60 | 0.45–0.81 | 0.001 | 0.36 | 0.19–0.69 | 0.002 | 0.40 | 0.21–0.76 | 0.006 |
Darunavir + Ritonavir | 6 | 0.71 | 0.50–1.02 | 0.067 | 0.65 | 0.45–0.95 | 0.027 | 0.64 | 0.28–1.46 | 0.29 | 0.47 | 0.20–1.09 | 0.08 |
Nelfinavir without booster | 28 | 0.97 | 0.87–1.09 | 0.66 | 0.96 | 0.84–1.09 | 0.50 | 7.77 | 4.05–14.91 | <0.001 | 5.32 | 2.60–10.88 | <0.001 |
Indinavir without booster | 39 | 1.05 | 0.95–1.16 | 0.35 | 1.00 | 0.89–1.11 | 0.98 | 11.56 | 5.84–22.90 | <0.001 | 10.22 | 4.63–22.53 | <0.001 |
Saquinavir + Ritonavir | 4 | 0.55 | 0.15–2.0 | 0.37 | 0.47 | 0.11–2.12 | 0.33 | 1.63 | 0.23–11.68 | 0.63 | 1.05 | 0.14–7.58 | 0.97 |
Saquinavir without booster | 24 | 0.90 | 0.71–1.13 | 0.35 | 0.82 | 0.62–1.08 | 0.15 | 3.96 | 1.46–10.76 | 0.007 | 2.07 | 0.71–6.00 | 0.18 |
Amprenavir + Ritonavir | 3 | 1.55 | 0.82–2.93 | 0.18 | 1.37 | 0.66–2.85 | 0.39 | – | – | – | – | – | – |
Amprenavir without booster | 4 | 0.85 | 0.42–1.73 | 0.66 | 0.64 | 0.28–1.49 | 0.30 | 9.62 | 1.34–68.95 | 0.024 | 3.88 | 0.52–28.89 | 0.19 |
Integrase Inhibitor | 4 | 0.82 | 0.53–1.28 | 0.39 | 0.78 | 0.50–1.22 | 0.28 | 0.62 | 0.23–1.69 | 0.35 | 0.54 | 0.20–1.49 | 0.24 |