|
Healthy Control Children
|
RSV
|
Other Respiratory Viruses
|
Other Respiratory Viruses
|
Bacterial Infection
|
Bacterial Infection
|
---|
(Age-matched)
|
(Older children)
|
(Age-matched)
|
(Older children)
|
---|
|
Median
|
IQR
|
Median
|
IQR
|
Median
|
IQR
|
Median
|
IQR
|
Median
|
IQR
|
Median
|
IQR
|
---|
2-Hydroxyisobuterate (α)a
|
0.014
|
0.012
|
0.017
|
0.008
|
0.004
|
0.013
|
0.006
|
0.004
|
0.011
|
0.006
|
0.003
|
0.011
|
0.007
|
0.002
|
0.013
|
0.011
|
0.005
|
0.020
|
3-Hydroxyisovalerate (β)a
|
0.019
|
0.010
|
0.028
|
0.014
|
0.010
|
0.020
|
0.014
|
0.004
|
0.021
|
0.023
|
0.011
|
0.036
|
0.012
|
0.004
|
0.021
|
0.015
|
0.009
|
0.022
|
3-Indoxylsulfate (β)a
|
0.018
|
0.006
|
0.052
|
0.022
|
0.006
|
0.057
|
0.026
|
0.006
|
0.061
|
0.031
|
0.009
|
0.097
|
0.006
|
0.006
|
0.015
|
0.012
|
0.006
|
0.028
|
Acetoacetate (α,β)a
|
0.004
|
0.003
|
0.010
|
0.012
|
0.006
|
0.020
|
0.016
|
0.008
|
0.038
|
0.023
|
0.008
|
0.063
|
0.010
|
0.005
|
0.029
|
0.017
|
0.005
|
0.034
|
Acetone (α)a
|
0.006
|
0.006
|
0.009
|
0.013
|
0.007
|
0.027
|
0.010
|
0.006
|
0.029
|
0.008
|
0.004
|
0.035
|
0.011
|
0.005
|
0.047
|
0.011
|
0.003
|
0.044
|
Alanine (α)a
|
0.131
|
0.104
|
0.164
|
0.156
|
0.090
|
0.230
|
0.140
|
0.057
|
0.239
|
0.080
|
0.023
|
0.155
|
0.113
|
0.076
|
0.193
|
0.044
|
0.014
|
0.091
|
Betaine (β)a
|
0.205
|
0.094
|
0.514
|
0.425
|
0.058
|
0.932
|
0.171
|
0.036
|
0.424
|
0.010
|
0.007
|
0.223
|
0.044
|
0.014
|
0.178
|
0.013
|
0.008
|
0.018
|
Blue 1.06 (β)
|
2.165
|
1.675
|
2.954
|
1.967
|
1.520
|
2.276
|
2.040
|
1.531
|
2.352
|
1.231
|
0.393
|
2.131
|
1.880
|
0.200
|
2.620
|
1.033
|
0.832
|
1.797
|
Carnitine (α)a
|
0.037
|
0.013
|
0.066
|
0.014
|
0.008
|
0.039
|
0.013
|
0.006
|
0.051
|
0.017
|
0.010
|
0.041
|
0.009
|
0.004
|
0.022
|
0.013
|
0.007
|
0.033
|
Citrate (α)a
|
0.690
|
0.485
|
1.089
|
0.334
|
0.182
|
0.602
|
0.153
|
0.093
|
0.540
|
0.251
|
0.053
|
0.615
|
0.197
|
0.041
|
0.402
|
0.183
|
0.086
|
0.399
|
Creatine (α)a
|
0.513
|
0.251
|
1.082
|
0.029
|
0.015
|
0.206
|
0.125
|
0.035
|
0.725
|
0.031
|
0.021
|
0.259
|
0.039
|
0.017
|
0.195
|
0.017
|
0.008
|
0.035
|
Ethanolamine (α,β)a
|
0.084
|
0.069
|
0.107
|
0.126
|
0.098
|
0.181
|
0.096
|
0.072
|
0.155
|
0.086
|
0.051
|
0.169
|
0.112
|
0.081
|
0.148
|
0.065
|
0.041
|
0.085
|
Fumarate (α,β)a
|
0.003
|
0.001
|
0.006
|
0.006
|
0.001
|
0.010
|
0.002
|
0.001
|
0.008
|
0.002
|
0.002
|
0.349
|
0.001
|
0.001
|
0.004
|
0.001
|
0.001
|
0.001
|
Glucose (α)a
|
0.096
|
0.067
|
0.136
|
0.170
|
0.103
|
0.258
|
0.189
|
0.145
|
0.217
|
0.066
|
0.031
|
0.191
|
0.293
|
0.115
|
0.907
|
0.062
|
0.034
|
0.156
|
Glutamate (β)a
|
0.010
|
0.010
|
0.010
|
0.037
|
0.010
|
0.076
|
0.010
|
0.010
|
0.066
|
0.010
|
0.010
|
0.087
|
0.010
|
0.010
|
0.044
|
0.013
|
0.010
|
0.064
|
Glutamine (α)a
|
0.139
|
0.112
|
0.153
|
0.215
|
0.140
|
0.337
|
0.187
|
0.134
|
0.295
|
0.218
|
0.076
|
0.529
|
0.188
|
0.077
|
0.378
|
0.052
|
0.022
|
0.191
|
Hippurate (β)a
|
0.160
|
0.083
|
0.292
|
0.104
|
0.038
|
0.219
|
0.137
|
0.038
|
0.290
|
0.236
|
0.111
|
0.464
|
0.538
|
0.103
|
0.992
|
0.173
|
0.070
|
0.306
|
Hypoxanthine (α)a
|
0.015
|
0.009
|
0.023
|
0.019
|
0.008
|
0.024
|
0.019
|
0.002
|
0.027
|
0.010
|
0.008
|
0.018
|
0.006
|
0.002
|
0.030
|
0.013
|
0.006
|
0.017
|
Lactate (α)a
|
0.032
|
0.026
|
0.047
|
0.052
|
0.037
|
0.074
|
0.057
|
0.043
|
0.084
|
0.030
|
0.017
|
0.049
|
0.051
|
0.040
|
0.075
|
0.012
|
0.011
|
0.038
|
Lysine (α)a
|
0.011
|
0.006
|
0.047
|
0.056
|
0.035
|
0.128
|
0.029
|
0.006
|
0.063
|
0.006
|
0.005
|
0.020
|
0.070
|
0.029
|
0.108
|
0.028
|
0.016
|
0.061
|
Methanol (α)a
|
0.001
|
0.001
|
0.008
|
0.014
|
0.008
|
0.018
|
0.012
|
0.008
|
0.020
|
0.002
|
0.001
|
0.008
|
0.012
|
0.009
|
0.036
|
0.006
|
0.003
|
0.011
|
N,N-Dimethylglycine (β)a
|
0.048
|
0.030
|
0.067
|
0.066
|
0.028
|
0.104
|
0.031
|
0.017
|
0.144
|
0.007
|
0.003
|
0.042
|
0.024
|
0.006
|
0.098
|
0.004
|
0.002
|
0.007
|
Pantothenate (β)
|
0.021
|
0.015
|
0.029
|
0.018
|
0.011
|
0.024
|
0.019
|
0.012
|
0.028
|
0.007
|
0.002
|
0.010
|
0.009
|
0.001
|
0.017
|
0.005
|
0.001
|
0.016
|
Propylene glycol (α)
|
0.018
|
0.002
|
0.089
|
0.053
|
0.019
|
0.136
|
0.073
|
0.017
|
0.172
|
0.017
|
0.008
|
0.045
|
0.068
|
0.018
|
0.336
|
0.024
|
0.007
|
0.084
|
Pyruvate (α)a
|
0.009
|
0.006
|
0.012
|
0.016
|
0.009
|
0.059
|
0.022
|
0.012
|
0.091
|
0.003
|
0.000
|
0.020
|
0.007
|
0.001
|
0.018
|
0.003
|
0.001
|
0.010
|
Serine (α,β)
|
0.075
|
0.020
|
0.123
|
0.197
|
0.146
|
0.282
|
0.179
|
0.020
|
0.281
|
0.020
|
0.014
|
0.148
|
0.264
|
0.102
|
0.302
|
0.035
|
0.020
|
0.208
|
Succinate (β)a
|
0.128
|
0.062
|
0.165
|
0.099
|
0.062
|
0.140
|
0.062
|
0.027
|
0.075
|
0.059
|
0.020
|
1.942
|
0.029
|
0.015
|
0.071
|
0.014
|
0.004
|
0.023
|
Tartrate (β)
|
0.008
|
0.001
|
0.016
|
0.018
|
0.005
|
0.030
|
0.012
|
0.001
|
0.026
|
0.003
|
0.001
|
0.051
|
0.004
|
0.001
|
0.030
|
0.001
|
0.001
|
0.002
|
Taurine (α)a
|
0.253
|
0.174
|
0.395
|
0.160
|
0.050
|
0.345
|
0.112
|
0.061
|
0.703
|
0.103
|
0.073
|
0.309
|
0.115
|
0.051
|
0.265
|
0.170
|
0.082
|
0.344
|
Threonine (β)
|
0.046
|
0.036
|
0.063
|
0.058
|
0.038
|
0.098
|
0.052
|
0.040
|
0.131
|
0.030
|
0.008
|
0.087
|
0.075
|
0.036
|
0.112
|
0.026
|
0.010
|
0.151
|
Uracil (β)a
|
0.009
|
0.001
|
0.016
|
0.013
|
0.001
|
0.018
|
0.011
|
0.001
|
0.024
|
0.007
|
0.004
|
16.34
|
0.001
|
0.001
|
0.026
|
0.001
|
0.001
|
0.011
|
Urea (α)a
|
33.60
|
23.80
|
49.10
|
33.20
|
22.90
|
50.67
|
50.83
|
23.36
|
73.76
|
27.94
|
12.87
|
40.72
|
47.22
|
24.11
|
83.14
|
39.75
|
28.99
|
47.18
|
trans-Aconitate (α)a
|
0.019
|
0.006
|
0.043
|
0.002
|
0.002
|
0.008
|
0.002
|
0.002
|
0.009
|
0.002
|
0.001
|
0.002
|
0.002
|
0.002
|
0.002
|
0.002
|
0.002
|
0.009
|
- The metabolites used to discriminate the different groups of subjects are labeled as: (α) required for separation of Healthy Infants vs RSV infection; (β) required for separation of RSV vs. Bacteria. Metabolites labelled witha are known to be endogenously produced within the human body