Per patient efficacy study | Per protocol N = 413 | Intent to treat N = 470 | ||
---|---|---|---|---|
RR (95 % CI) | % Weight | RR (95 % CI) | % Weight | |
Salmanpour R [15] | 0.93 (0.64−1.37) | 21.4 | 0.93 (0.64−1.37) | 21.5 |
Layegh P [10] | 2.10 (1.16−3.81) | 18.6 | 2.05 (1.11−3.77) | 18.6 |
López P [20] | 0.40 (0.29−0.55) | 22.2 | 0.35 (0.25−0.50) | 21.9 |
Negera E [14] | 1.04 (0.88−1.23) | 23.5 | 0.95 (0.77−1.17) | 23.2 |
Soto J [13] | 0.29 (0.11−0.71) | 14.3 | 0.29 (0.11−0.71) | 14.7 |
Overall random effects | 0.78 (0.45−1.34) | 0.73 (0.42−1.29) | ||
Sensitivity analysis | Relative change | Relative change | ||
Salmanpour R [15] | 0.73 (0.36−1.50) | −5.71 | 0.68 (0.33−1.45) | −7.04 |
Layegh P [10] | 0.62 (0.35−1.11) | −19.9 | 0.58 (0.33−1.05) | −20.39 |
López P [20] | 0.97 (0.62−1.55) | 25.2 | 0.94 (0.59−1.48) | 27.05 |
Negera E [14] | 0.71 (0.33−1.53) | −9.3 | 0.67 (0.30−1.53) | −8.09 |
Soto J [13] | 0.92 (0.52−1.61) | 18.0 | 0.86 (0.48−1.56) | 17.55 |
Overall random effects | 0.78 (0.45−1.34) | 0.73 (0.42−1.29) | ||
Heterogeneity | ||||
Dersimonian- Laird's Q Statistic | 42.69. p-value = 0.000 | 39.08. p-value = 0.000 | ||
RI Coefficient | 0.934 | 0.889 | ||
Variation Coef. | 4.259 | 2.468 | ||
Variance between studies | 0,317 | 0,343 | ||
Variance within studies | 0,022 | 0,031 | ||
No publication bias | ||||
Begg’s test, Z Statistic | 0.2449. p-value = 0.806 | 0.2449. p-value = 0.403 | ||
Egger’s test, t Statistic | −1.0877. p-value = 0.356 | 0.7560. p-value = 0.505 |