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Table 5 Meta-analysis of the per patient efficacy of cryotherapy compared to pentavalent antimonials

From: Efficacy of cryotherapy for the treatment of cutaneous leishmaniasis: meta-analyses of clinical trials

Per patient efficacy study Per protocol N = 413 Intent to treat N = 470
RR (95 % CI) % Weight RR (95 % CI) % Weight
Salmanpour R [15] 0.93 (0.64−1.37) 21.4 0.93 (0.64−1.37) 21.5
Layegh P [10] 2.10 (1.16−3.81) 18.6 2.05 (1.11−3.77) 18.6
López P [20] 0.40 (0.29−0.55) 22.2 0.35 (0.25−0.50) 21.9
Negera E [14] 1.04 (0.88−1.23) 23.5 0.95 (0.77−1.17) 23.2
Soto J [13] 0.29 (0.11−0.71) 14.3 0.29 (0.11−0.71) 14.7
Overall random effects 0.78 (0.45−1.34)   0.73 (0.42−1.29)  
Sensitivity analysis   Relative change   Relative change
Salmanpour R [15] 0.73 (0.36−1.50) −5.71 0.68 (0.33−1.45) −7.04
Layegh P [10] 0.62 (0.35−1.11) −19.9 0.58 (0.33−1.05) −20.39
López P [20] 0.97 (0.62−1.55) 25.2 0.94 (0.59−1.48) 27.05
Negera E [14] 0.71 (0.33−1.53) −9.3 0.67 (0.30−1.53) −8.09
Soto J [13] 0.92 (0.52−1.61) 18.0 0.86 (0.48−1.56) 17.55
Overall random effects 0.78 (0.45−1.34)   0.73 (0.42−1.29)  
Heterogeneity     
Dersimonian- Laird's Q Statistic 42.69. p-value = 0.000   39.08. p-value = 0.000  
RI Coefficient 0.934   0.889  
Variation Coef. 4.259   2.468  
Variance between studies 0,317    0,343
Variance within studies 0,022    0,031
No publication bias     
Begg’s test, Z Statistic 0.2449. p-value = 0.806   0.2449. p-value = 0.403  
Egger’s test, t Statistic −1.0877. p-value = 0.356   0.7560. p-value = 0.505  
  1. RR (95 % CI) relative risk with its 95 % confidence interval