Ventricular assist devices as bridge to heart transplantation: impact on post-transplant infections

BMC Infectious Diseases

Table 5 Multivariate analysis of risk factors for infection after heart transplantation

	Bacterial and candida infection			All fungal infections			Viral infections
	Hazard ratio	95 % CI	p-value	Hazard ratio	95 % CI	p-value	Hazard ratio	95 % CI	p-value
Recipient age^a	0.89	0.67-1.19	0.43	1.30	0.77-2.21	0.32	0.91	0.68-1.20	0.49
Recipient male gender	2.06	0.85-5.01	0.11	0.98	0.22-4.32	0.98	1.59	0.62-4.10	0.33
Donor age^a	1.03	0.81 – 1.31	0.81	1.10	0.74 – 1.63	0.64	0.92	0.70 – 1.20	0.54
Donor male gender	1.88	0.91 – 3.89	0.09	0.76	0.27 – 2.20	0.62	0.50	0.23 – 1.06	0.07
VAD pre-transplant				0.27^b	0.06-1.30	0.10
- Continuous-flow device	0.94	0.38- 2.32	0.89				0.91	0.32 – 2.56	0.86
- Other device	0.45	0.15 - 1.34	0.15				0.64	0.18 – 2.22	0.48
Diabetes	1.48	0.69-3.20	0.32	2.74	0.87-8.57	0.08	2.01	0.82-5.31	0.12
Post-transplant cotrimoxazole prophylaxis	0.29	0.15-0.57	<0.001	1.04	0.36-3.01	0.95	1.03	0.49-2.17	0.94
Transplant center
Center A (ref.)	1			1			1
Center B	0.69	0.32 – 1.49	0.35	1.38	0.40-4.78	0.61	1.06	0.46-2.45	0.89
Center C	0.55	0.23 – 1.31	0.18	0.28	0.04-1.78	0.18	0.50	0.18-1.44	0.20
Induction therapy
No induction(ref.)	1			1			1
ATG	1.01	0.35 – 2.96	0.98	0.18	0.02-1.37	0.10	1.20	0.34-4.25	0.78
Basiliximab	1.57	0.42 – 5.92	0.50	0.40	0.03-5.58	0.50	-	-	-
Use of everolimus	0.34	0.08 – 1.49	0.15	2.24	0.54-9.33	0.27	0.90	0.28-2.86	0.86

VAD ventricular-assist device, ATG anti-thymocyte globulin
^aFor ten years age difference
^bNo patient in the “other device” group developed a fungal infection, so the specific hazard ratio for this subgroup could not be calculated

ISSN: 1471-2334