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Table 5 Predictors of disability and outcome on univariate analysis in patients with tuberculous meningitis

From: Paradoxical reaction in tuberculous meningitis: presentation, predictors and impact on prognosis

Characteristics

BI≤12 (n=50)

BI>12 (n=91)

P value

Odds Ratio

95 % Confidence interval

Lower bound

Upper bound

Age

29.320±11.881

29.989±13.322

.768

 

−3.797

5.135

Duration of illness

42.140±21.204

53.560±27.761

.013

 

2.495

20.345

Gender

22(44 %)

54(59.3 %)

.080

.538

.268

1.082

HIV

      

Fever

49(98 %)

89(97.8 %)

.938

1.101

.097

12.453

Headache

44(88 %)

87(95.6 %)

.092

.337

.090

1.257

Seizure

15(30.0 %)

33(36.3 %)

.453

.753

.359

1.580

Altered Sensorium

31(62.0 %)

13(14.3 %)

<.001

9.789

4.316

22.206

Decreased vision

16(32.0 %)

19(20.9 %)

.144

1.783

.817

3.891

Hemiparesis

9(18.0 %)

14(15.4 %)

.688

1.207

.482

3.027

Paraparesis

6(12.0 %)

6(6.6 %)

.271

1.932

.588

6.342

Meningeal signs

44(88.0 %)

81(89 %)

.856

.905

.308

2.657

Lymphadenopathy

4(8.0 %)

9(9.9 %)

.711

.792

.231

2.716

Diplopia

19(38.0 %)

40(44.0 %)

.493

.821

.402

1.675

Cranial Nerve involvement

28(56.0 %)

52(57.1 %)

.896

.955

.476

1.914

Papilloedema

18(36.0 %)

37(40.7 %)

.587

.821

.402

1.675

Hydrocephalus

40(80.0 %)

13(14.3 %)

<.001

24.0

9.677

59.520

Basal Exudates

12(24.0 %)

26(28.6 %)

.558

.789

.357

1.744

Tuberculoma

22(44.0 %)

29(31.9 %)

.151

1.680

.825

3.422

Infarct

9(18.0 %)

16(17.6 %)

.950

1.029

.418

2.533

Optochiasmatic arachnoiditis

7(14.0 %)

14(15.4 %)

.825

.895

.336

2.388

Spinal arachnoiditis

6(12.0 %)

6(6.6 %)

.271

1.932

.588

6.342

Stage-III TBM

31(62.0 %)

13(14.3 %

<.001

9.789

4.316

22.206

Definite TBM

23(46.0 %)

31(34.1 %)

.163

   

Paradoxical reaction

12(24.0 %)

32(35.2 %)

.171

.582

.267

1.268

CSF Cells

159.340

206.242

.152

 

−17.474

111.277

CSF protein

256.772

252.019

.953

 

−163.99

154.488

CSF sugar

35.112

35.422

.925

 

−6.153

6.773

  1. CSF cerebrospinal fluid, HIV human immunodeficiency virus, BI Barthel index, TBM tuberculous meningitis
  2. Note: Statistically significant P-values are depicted in italics