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Table 5 Predictors of disability and outcome on univariate analysis in patients with tuberculous meningitis

From: Paradoxical reaction in tuberculous meningitis: presentation, predictors and impact on prognosis

Characteristics BI≤12 (n=50) BI>12 (n=91) P value Odds Ratio 95 % Confidence interval
Lower bound Upper bound
Age 29.320±11.881 29.989±13.322 .768   −3.797 5.135
Duration of illness 42.140±21.204 53.560±27.761 .013   2.495 20.345
Gender 22(44 %) 54(59.3 %) .080 .538 .268 1.082
HIV       
Fever 49(98 %) 89(97.8 %) .938 1.101 .097 12.453
Headache 44(88 %) 87(95.6 %) .092 .337 .090 1.257
Seizure 15(30.0 %) 33(36.3 %) .453 .753 .359 1.580
Altered Sensorium 31(62.0 %) 13(14.3 %) <.001 9.789 4.316 22.206
Decreased vision 16(32.0 %) 19(20.9 %) .144 1.783 .817 3.891
Hemiparesis 9(18.0 %) 14(15.4 %) .688 1.207 .482 3.027
Paraparesis 6(12.0 %) 6(6.6 %) .271 1.932 .588 6.342
Meningeal signs 44(88.0 %) 81(89 %) .856 .905 .308 2.657
Lymphadenopathy 4(8.0 %) 9(9.9 %) .711 .792 .231 2.716
Diplopia 19(38.0 %) 40(44.0 %) .493 .821 .402 1.675
Cranial Nerve involvement 28(56.0 %) 52(57.1 %) .896 .955 .476 1.914
Papilloedema 18(36.0 %) 37(40.7 %) .587 .821 .402 1.675
Hydrocephalus 40(80.0 %) 13(14.3 %) <.001 24.0 9.677 59.520
Basal Exudates 12(24.0 %) 26(28.6 %) .558 .789 .357 1.744
Tuberculoma 22(44.0 %) 29(31.9 %) .151 1.680 .825 3.422
Infarct 9(18.0 %) 16(17.6 %) .950 1.029 .418 2.533
Optochiasmatic arachnoiditis 7(14.0 %) 14(15.4 %) .825 .895 .336 2.388
Spinal arachnoiditis 6(12.0 %) 6(6.6 %) .271 1.932 .588 6.342
Stage-III TBM 31(62.0 %) 13(14.3 % <.001 9.789 4.316 22.206
Definite TBM 23(46.0 %) 31(34.1 %) .163    
Paradoxical reaction 12(24.0 %) 32(35.2 %) .171 .582 .267 1.268
CSF Cells 159.340 206.242 .152   −17.474 111.277
CSF protein 256.772 252.019 .953   −163.99 154.488
CSF sugar 35.112 35.422 .925   −6.153 6.773
  1. CSF cerebrospinal fluid, HIV human immunodeficiency virus, BI Barthel index, TBM tuberculous meningitis
  2. Note: Statistically significant P-values are depicted in italics