Skip to main content

Table 2 Ribosomal and tRNA associated genes down-regulated in M. tuberculosis exposed to PZA under slow growth

From: The effect of growth rate on pyrazinamide activity in Mycobacterium tuberculosis - insights for early bactericidal activity?

Gene expression fold change from pre-PZA to early recovery phase (100 μgml−1 for 4 h) Gene expression fold change from pre-PZA to iv) late recovery phase (100 μgml−1 for 2 MGT) Gene name UniProt ID Annotation
−4.81 −11.22 tRNA-Val   tRNA-Val
−3.23 −10.01 tRNA-Glu   tRNA-Glu
−3.99 −9.34 tRNA-Lys   tRNA-Lys
−5.13 −8.95 Rv0700 P0A5X0 30S ribosomal protein S10
−2.63 −8.62 tRNA-Gly   tRNA-Gly
−3.52 −8.60 tRNA-Thr   tRNA-Thr
−4.86 −8.15 tRNA-Arg   tRNA-Arg
−5.22 −7.36 Rv0704 P95052 50S ribosomal protein L2
−4.49 −7.33 tRNA-Met   tRNA-Met
−4.68 −6.35 Rv0703 P95051 50S ribosomal protein L23
−4.29 −6.16 Rv1298 P66187 50S ribosomal protein L31
−1.65 −6.13 tRNA-Leu   tRNA-Leu
−2.33 −5.97 tRNA-Ser   tRNA-Ser
−4.08 −5.88 Rv0710 P95058 30S ribosomal protein S17
−1.65 −5.43 tRNA-Pro   tRNA-Pro
−3.70 −5.20 Rv0705 P0A5X4 30S ribosomal protein S19
−1.44 −4.83 tRNA-Tyr   tRNA-Tyr
−3.56 −4.82 Rv0709 P95057 50S ribosomal protein L29
−4.32 −4.82 Rv0702 P60729 50S ribosomal protein L4
−3.99 −4.72 Rv0722 P66181 50S ribosomal protein L30
−3.09 −4.66 Rv0701 P60442 50S ribosomal protein L3
−3.76 −4.17 Rv0716 P62403 50S ribosomal protein L5
−3.32 −3.98 Rv0717 P0A5X2 30S ribosomal protein S14 type Z
−3.48 −3.79 Rv0682 P41196 30S ribosomal protein S12
−3.01 −3.69 Rv0715 P60627 50S ribosomal protein L24
1.03 −3.68 tRNA-Cys   tRNA-Cys
−3.45 −3.61 Rv1643 P66105 50S ribosomal protein L20
−2.99 −3.56 Rv0723 P95071 50S ribosomal protein L15
−1.44 −3.38 tRNA-Trp   tRNA-Trp
−2.97 −3.32 Rv2412 P66505 30S ribosomal protein S20
−3.07 −3.22 Rv0683 P41194 30S ribosomal protein S7
−4.07 −3.05 Rv0718 P66625 30S ribosomal protein S8
−3.13 −3.04 Rv1642 P66271 50S ribosomal protein L35
−2.59 −3.02 Rv0714 P66069 50S ribosomal protein L14
−2.79 −2.92 Rv0707 P0A5X6 30S ribosomal protein S3
−1.06 −2.91 5S_rRNA   ribosomal RNA
−2.44 −2.91 Rv0721 P66574 30S ribosomal protein S5
1.03 −2.84 tRNA-Asp   tRNA-Asp
−1.14 −2.67 tRNA-His   tRNA-His
−1.10 −2.65 tRNA-Phe   tRNA-Phe
−1.45 −2.64 tRNA-Ile   tRNA-Ile
1.00 −2.45 23S rRNA   ribosomal RNA
−1.41 −2.39 Rv0640 P66056 50S ribosomal protein L11
1.00 −2.27 16S rRNA   Ribosomal RNA
−2.01 −2.27 Rv0720 P66076 50S ribosomal protein L18
−1.84 −2.17 Rv0719 P66311 50S ribosomal protein L6
−2.15 −2.07 Rv0055 P69230 30S ribosomal protein S18 1
−1.67 −2.03 Rv1630 O06147 30S ribosomal protein S1
−2.35 −1.92 Rv1644 P94978 possible 23S rRNA methyltransferase tsnR
  1. Genes encoding tRNAs or ribosome component proteins that were down-regulated by at least two fold (with an ANOVA p –value of less than 0.05) in M. tuberculosis under slow growth in the early recovery phase (4 h after the addition of 100 μgml−1 PZA) and/or the late recovery phase (2 MGT after the addition of 100 μgml−1 PZA) compared to the pre-PZA phase