Do piperacillin/tazobactam and other antibiotics with inhibitory activity against Clostridium difficile reduce the risk for acquisition of C. difficile colonization?

Table 1 Minimum Inhibitory Concentrations (MICs) of Commonly Used Antibiotics against the Clostridium difficile Test Strain

Antibiotic	MIC (μg/mL)^a
Imipenem	2
Meropenem	2
Ampicillin	2
Piperacillin/tazobactam	2
Sulfamethoxazole/trimethoprim	32
Tetracycline	0.5
Ciprofloxacin	128
Moxifloxacin	64
Ceftriaxone	32
Clindamycin	>256
Metronidazole	0.25
Linezolid	0.5

^aMICs were determined by broth dilution. The test strain (VA 17) is an epidemic NAP1/027/BI strain

ISSN: 1471-2334