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Table 1 Meta-analysis of the association between nutritional status and the severity of dengue. Pooled odds ratios (OR) with corresponding 95 % confidence intervals (95 % CI) of the published results were calculated where more than one study had investigated the factor

From: Association between nutritional status and dengue infection: a systematic review and meta-analysis

Variable No. of study Total sample size (DSS/DHF) Heterogeneity Model Association with severity Egger’s 2-tailed bias p-value
p-value I 2 p-value Odds ratio (95 % CI) p-value after removing 1 study
Malnutrition (DSS vs. DHF) All methods 10 1741/3497 0 · 32 13 Fixed 0 · 072 1.17(0.99–1.39)   0.01
        1.27(1.09–1.49)a
Malnutrition (DSS vs. DHF) 7 1398/3010 0 · 43 0 Fixed 0.031 1.25(1.02–1.53)   0.04
Weight for age 1.40(1.16–1.69)a
Malnutrition (DSS + DHF vs. DF) 3 3897/894 0 · 89 0 Fixed 0.028 0.77(0.61–0.97)   
Malnutrition (DHFvs.DF) 5 2745/1006 0 · 38 4 Fixed 0.005 0.71(0.56–0.90) 0.84 0.12
Malnutrition (Combined dengue vs. healthy) (weight for age) 3 473/791 0.20 39 Fixed <0.001 :0 · 46(0 · 30–0 · 70)   
Malnutrition (DSS + DHF vs. healthy) (weight for age) 2 345/717 0.17 47 Fixed <0.001 :0 · 44(0 · 29–0 · 67)   
Normal nutrition (DSS vs. DHF) All methods 9 1616/3398 0 · 26 21 Fixed 0 · 03 0 · 87(0 · 77–0 · 99) 0 · 20 0 · 43
Obesity/overweight (DSS vs. DHF) All methods 8 1513/3187 0 · 05 51 Random 0 · 15 1 · 31(0 · 91–1 · 88)   0 · 32
  1. aOR: adjusted odds ratio calculated after the addition of potential missing studies using the trim and fill method of Duvall and Tweedie