Emerging pan-resistance in Trichosporon species: a case report

BMC Infectious Diseases

Table 1 MICs of various antifungal agents against 11 clinical Trichosporon dermatis isolates

T. dermatis strains tested	MIC (mg/liter)														Method	Reference
	Amphotericin B^a		Flucytosine		Fluconazole		Itraconazole		Voriconazole		Posaconazole		Caspofungin
	GM	Range	GM	Range	GM	Range	GM	Range	GM	Range	GM	Range	GM	Range
1	0.25		>64		>256		>16		>16		>8		>16		Sensititre^b	Our study
8	0.24	0.015-16.0	58.6	16.0-128.0	12.3	1.0-128.0	0.58	0.06-8.0	0.48	0.06-16.0	ND		ND		Eucast	Rodriguez-Tudela et al 2005 [7]
1	0.5		8				0.06		0.06		ND		16		CLSI	Chagas-Neto et al 2009 [2]
1	0.13		ND		2		0.06		0.06		0.015		ND		Eucast	Taverna et al. 2014 [16]

GM geometrical mean, MIC minimal inhibitory concentration, ND not done
^aEffectiveness of amphotericin B is limited in Trichosporon infections [12]
^bSusceptibility was tested using a commercial microdilution test (Yeast Sensititre OneTM) by the national reference center (Radboud University Medical Center, Nijmegen, The Netherlands)

ISSN: 1471-2334