Skip to main content

Table 4 Pharmacokinetic non-compartmental results of isoniazid in fast and slow acetylators

From: Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis

Isoniazid SLOW FAST % difference
Number of patients enrolleda 28 64  
Body Weight (median kg - range) 10.0 (4.5–26.0) 13.0 (4.4–44.0)  
Age (median months - range) 36 (6–180) 42 (2–180)  
Dosage (mean - % CV) 4.82 (11.7) 4.70 (13.3) p-value: > 0.05b
CMAX (ug/mL) 4.56 4.62 −1.3
TMAX (hr) 1 2 −50
CL/F (L/hr) 2.28 2.47 −7.69
CL/F/BW (L/hr/kg) 0.23 0.19 21.1
V/F (L) 12.2 7.05 72.3
V/F/BW (L/kg) 1.21 0.54 124
T1/2 (hr) 3.69 1.98 86.4
AUC0-∞ (hr × ug/mL) 21.9 22.8 −3.78
AUC0-∞/dosage (hr × ug/mL/(mg/kg)) 4.38 4.95 −11.5
T > MIC (hr) 14.8 11.9 24.7
T > MIC/24 h (%) 61.7 49.4 24.8
AUC0–24 h > MIC (hr × ug/mL) 17.7 19.8 −10.7
  1. aAcetylator genotype was determined in 92 patients. bMann–Whitney T-test. Apart for dosage with mean and % CV, all values are reported as median (range) or as median estimates for pharmacokinetic parameters. C MAX maximum observed plasma concentration after oral administration, T MAX observed time to reach CMAX, CL/F oral elimination clearance, CL/F/BW elimination clearance corrected by the median body weight, V/F apparent volume of distribution, V/F/BW apparent volume of distribution corrected by the median body weight, T 1/2 terminal elimination half-life, AUC 0-∞ predicted area under the plasma concentration-time curve after the last dose from zero time to infinity, T > MIC time above the minimum inhibitory concentration, T > MIC/24 h percentage of the time above the minimum inhibitory concentration over the 24 h dose interval, AUC > MIC observed area under the plasma concentration-time curve above the minimum inhibitory concentration. % difference is calculated with the > 4 years group used as the reference