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Table 2 Pharmacokinetic non-compartmental results of pyrazinamide in children above and below 4 years of age

From: Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis

Pyrazinamide <4 years old >4 years old % difference
Number of patients enrolled 64 36  
Body Weight (median kg - range) 9.0 (4.0–15.0) 19.0 (13.5–43.0)  
Age (median months - range) 12 (2–48) 96 (48–180)  
Dosage (mean - % CV) 4.70 (12.8) 5.12 (9.18) p-value: 0.0001a
CMAX (ug/mL) 30.1 37.4 −19.5
TMAX (hr) 2 3 −33.3
CL/F (L/hr) 1.09 1.88 −42
CL/F/BW (L/hr/kg) 0.12 0.1 20
V/F (L) 7.57 12.2 −37.9
V/F/BW (L/kg) 0.84 0.64 31.3
T1/2 (hr) 4.82 4.5 7.11
AUC0-∞ (hr × ug/mL) 245 284 −13.7
AUC0-∞/dosage (hr × ug/mL/(mg/kg)) 10.1 10.8 −6.2
T > MIC (hr) 7.28 8.46 −13.9
T > MIC/24 h (%) 30.3 35.2 −13.9
AUC > MIC (hr × ug/mL) 62.3 95.2 −34.6
  1. Apart for dosage with mean and % CV, all values are reported as median (range) or as median estimates for pharmacokinetic parameters. C MAX maximum observed plasma concentration after oral administration, T MAX observed time to reach CMAX, CL/F oral elimination clearance, CL/F/BW elimination clearance corrected by the median body weight, V/F apparent volume of distribution, V/F/BW apparent volume of distribution corrected by the median body weight, T 1/2 terminal elimination half-life, AUC 0-∞ predicted area under the plasma concentration-time curve after the last dose from zero time to infinity, T > MIC time above the minimum inhibitory concentration, T > MIC/24 h percentage of the time above the minimum inhibitory concentration over the 24 h dose interval, AUC > MIC observed area under the plasma concentration-time curve above the minimum inhibitory concentration. % difference is calculated with the > 4 years group used as the reference. aMann–Whitney T-test