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Table 2 Quality assessment of included cross-sectional control studies

From: The diagnostic accuracy of serological tests for Lyme borreliosis in Europe: a systematic review and meta-analysis

Author_Year Design RoB_P CrA_P RoB_I CrA_I RoB_RS CrA_RS RoB_TaF
Albisetti 1997 Cross sectional Low Low Unclear Low Low Low Unclear
Barrial 2011 Cross sectional Unclear Unclear Low Low Low Low Low
Bazovska 2001 Cross sectional Unclear Unclear Unclear Low Unclear Low Low
Bednarova 2006 Cross sectional Unclear Unclear Unclear Low Unclear Low Unclear
Bennet 2008 Cross sectional Unclear High Unclear Low Unclear Low Unclear
Blaauw 1993 Cross sectional Low Low High High Low Low Low
Blaauw 1999 Cross sectional Low High Unclear High/Low* Low Low Unclear
Blanc 2007 Cross sectional Unclear Unclear Unclear Low High Low Unclear
Cermakova 2005 Cross sectional Low Low Unclear Low High Low Low
Davidson 1999 Cross sectional Unclear Unclear Unclear High/Low* High High Low
Ekerfelt 2004 Cross sectional Unclear Unclear Low Low Unclear Low Unclear
Jansson 2005 Cross sectional Unclear Unclear Unclear Low High High Low
Kolmel 1992 Cross sectional Unclear Unclear Unclear Low High Low Unclear
Ljostad 2005 Cross sectional High High Unclear Unclear Low Low Low
Popperl 2000 Cross sectional Unclear Unclear Unclear Low High High Low
Roux 2007 Cross sectional High Unclear Unclear High/Low* Low High Unclear
Skarpaas 2007 Cross sectional Low Low High/Unclear* Low Unclear Low Unclear
Skogman 2008 Cross sectional Unclear Unclear High High Low Low Low
  1. RoB_P: Risk of Bias in patient sampling; RoB_I: Risk of Bias in Index test; RoB_RS: Risk of Bias in Reference Standard; RoB_TaF: Risk of Bias in timing and flow. CrA_P: Concerns regarding applicability of patient sample; CrA_I: Concerns regarding applicability of Index Test; CrA_RS: Concerns regarding applicability of Reference Standard. * some studies evaluated more than one test and evaluated these in different ways (e.g. for one test the cut-off value was pre-specified, while for the other test it was based on the results)