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Table 2 Results of the quality assessment according to the QUADAS-2 tool

From: Performance of interferon-γ release assays in the diagnosis of confirmed active tuberculosis in immunocompetent children: a new systematic review and meta-analysis

  Risk for bias Applicability concerns
Study Patient selection Index test Reference standard Flow and timing Patient selection Index test Reference standard
Detjen et al. (2007) [27] H L L L L L L
Domínguez et al. (2008) [28] U H L U L L L
Kampmann et al. (2009) [29] H L L L L L L
Lighter et al. (2009) [30] H U U L L L L
Hansted et al. (2009) [31] L H L L L L L
Bamford et al. (2010) [32] H L L H L L L
Sun Lin et al. (2010) [33] H L H H L L L
Tsolia et al. (2010) [34] L U H H L L L
Cruz et al. (2011) [35] H H L H L L L
Chiappini et al. (2012) [36] L H L L L L L
Lodha et al. (2013) [37] H U U L L L L
Blandinières et al. (2013) [38] H U U L L L L
Jenum et al. (2014) [39] L U U H L L L
Chiappini et al. (2014) [40] L U U H L L L
Petrone et al. (2015) [41] H U U H L L L
  1. H high risk for bias, U unclear risk for bias, L low risk for bias