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Table 2 Results of the quality assessment according to the QUADAS-2 tool

From: Performance of interferon-γ release assays in the diagnosis of confirmed active tuberculosis in immunocompetent children: a new systematic review and meta-analysis

 

Risk for bias

Applicability concerns

Study

Patient selection

Index test

Reference standard

Flow and timing

Patient selection

Index test

Reference standard

Detjen et al. (2007) [27]

H

L

L

L

L

L

L

Domínguez et al. (2008) [28]

U

H

L

U

L

L

L

Kampmann et al. (2009) [29]

H

L

L

L

L

L

L

Lighter et al. (2009) [30]

H

U

U

L

L

L

L

Hansted et al. (2009) [31]

L

H

L

L

L

L

L

Bamford et al. (2010) [32]

H

L

L

H

L

L

L

Sun Lin et al. (2010) [33]

H

L

H

H

L

L

L

Tsolia et al. (2010) [34]

L

U

H

H

L

L

L

Cruz et al. (2011) [35]

H

H

L

H

L

L

L

Chiappini et al. (2012) [36]

L

H

L

L

L

L

L

Lodha et al. (2013) [37]

H

U

U

L

L

L

L

Blandinières et al. (2013) [38]

H

U

U

L

L

L

L

Jenum et al. (2014) [39]

L

U

U

H

L

L

L

Chiappini et al. (2014) [40]

L

U

U

H

L

L

L

Petrone et al. (2015) [41]

H

U

U

H

L

L

L

  1. H high risk for bias, U unclear risk for bias, L low risk for bias