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Table 1 Patient characteristics for mild, moderate and severe infections

From: High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants

  Mild (n = 25) Moderate (n = 53) Severe (n = 27) P-value
Age (days) (median + IQR)a 191 (73–538) 134 (58–323) 38 (19–55) <0.001
Gestational age (weeks) (median + IQR)a 39 (37–40) 39 (37–40) 38 (37–39) NS
Male (%) 60 52 57 NS
Hospital duration (days) (median + IQR)a 1 (0–5) 6 (4–9) 11 (10–14) <0.001
Siblings (%) 60 79 89 0.037
Daycare (%) 68 50 15 0.001
Antibiotics in past 4 weeks (%) 28 8 19 NS
Vaccination according to Dutch immunisation program (%) 84 79 19 <0.001
RSV load (Ct value) (median + IQR)a 22 (21–27) 24 (22–30) 23 (21–27) NS
Viral co-infection (%) 64 46 21 0.007
  1. Data are presented as median + interquartile range (IQR) for continuous variables or in percentages for categorical variables. aShapiro–Wilk’s test was used to test data normality for continuous variables. Age, gestational age, hospital duration and RSV load were not normally distributed and therefore a Kruskal–Wallis H test was used for continuous variables. Categorical variables where tested using Chi-square analysis