High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants

Table 1 Patient characteristics for mild, moderate and severe infections

	Mild (n = 25)	Moderate (n = 53)	Severe (n = 27)	P-value
Age (days) (median + IQR)^a	191 (73–538)	134 (58–323)	38 (19–55)	<0.001
Gestational age (weeks) (median + IQR)^a	39 (37–40)	39 (37–40)	38 (37–39)	NS
Male (%)	60	52	57	NS
Hospital duration (days) (median + IQR)^a	1 (0–5)	6 (4–9)	11 (10–14)	<0.001
Siblings (%)	60	79	89	0.037
Daycare (%)	68	50	15	0.001
Antibiotics in past 4 weeks (%)	28	8	19	NS
Vaccination according to Dutch immunisation program (%)	84	79	19	<0.001
RSV load (Ct value) (median + IQR)^a	22 (21–27)	24 (22–30)	23 (21–27)	NS
Viral co-infection (%)	64	46	21	0.007

Data are presented as median + interquartile range (IQR) for continuous variables or in percentages for categorical variables. ^aShapiro–Wilk’s test was used to test data normality for continuous variables. Age, gestational age, hospital duration and RSV load were not normally distributed and therefore a Kruskal–Wallis H test was used for continuous variables. Categorical variables where tested using Chi-square analysis

ISSN: 1471-2334