| The 2009 WHO definitions | Sensitivity (95 % CI) | Specificity (95 % CI) | PPV (95 % CI) | NPV (95 % CI) | LR+ (95 % CI) | LR– (95 % CI) | |
---|---|---|---|---|---|---|---|---|
Severe (n = 20) | Non-severe (n = 105) | |||||||
Individual warning sign | ||||||||
 Abdominal pain | 9 | 44 | 45.0 (23.1–68.5) | 58.1 (48.1–67.7) | 17.0 (8.1–29.8) | 84.7 (74.3–92.1) | 1.1 (0.6–1.8) | 0.9 (0.6–1.4) |
 Persistent vomiting | 8 | 12 | 40.0 (19.1–64.0) | 88.6 (80.9–94.0) | 40.0 (19.1–64.0) | 88.6 (80.9–94.0) | 3.5 (1.6–7.4) | 0.7 (0.5–1.0) |
 Clinical fluid accumulation | 15 | 10 | 75.0 (50.9–91.3) | 90.5 (83.2–95.3) | 60.0 (38.7–78.9) | 95.0 (88.7–98.4) | 7.9 (4.2–15.0) | 0.3 (0.1–0.6) |
 Lethargy | 18 | 76 | 90.0 (68.3–98.8) | 27.6 (19.3–37.2) | 19.2 (11.8–28.6) | 93.6 (78.6–99.2) | 1.2 (1.0–1.5) | 0.4 (0.1–1.4) |
 Liver span of >15 cm | 12 | 17 | 60.0 (36.0–80.9) | 83.8 (75.4–90.3) | 41.4 (23.5–61.1) | 91.7 (84.2–96.3) | 3.7 (2.1–6.5) | 0.5 (0.3–0.8) |
 Mucosal bleeding | 14 | 39 | 70.0 (45.7–88.1) | 62.9 (52.9–72.1) | 26.4 (15.3–40.3) | 91.7 (82.7–96.9) | 1.9 (1.3–2.8) | 0.5 (0.2–1.0) |
 Hematocrit >2 % and platelets ≤100 × 103/μL | 12 | 42 | 60.0 (36.0–80.9) | 60.0 (50.0–69.4) | 22.2 (12.0–35.6) | 88.7 (79.0–95.0) | 1.5 (1.0–2.3) | 0.7 (0.4–1.2) |
Number of warning signs | ||||||||
  ≥ 1 | 20 | 95 | 100.0 (83.2–100.0) | 9.5 (4.7–16.8) | 17.4 (11.0–25.6) | 100.0 (69.2–100.0) | 1.1 (1.0–1.2) | 0 |
  ≥ 2 | 19 | 71 | 95.0 (75.1–99.9) | 32.4 (23.6–42.1) | 21.1 (13.2–31.0) | 97.1 (85.1–99.9) | 1.4 (1.2–1.7) | 0.2 (0–1.1) |
  ≥ 3 | 17 | 43 | 85.0 (62.1–96.8) | 59.0 (49.0–68.6) | 28.3 (17.4–41.4) | 95.4 (87.1–99.0) | 2.1 (1.6–2.8) | 0.2 (0.1–0.7) |
  ≥ 4 | 14 | 21 | 70.0 (45.7–88.1) | 80.0 (71.1–87.2) | 40.0 (23.9–57.9) | 93.3 (86.0–97.5) | 3.5 (2.2–5.6) | 0.4 (0.2–0.7) |
  ≥ 5 | 11 | 8 | 55.0 (31.5–76.9) | 92.4 (85.5–96.6) | 57.9 (33.5–79.8) | 91.5 (84.5–96.0) | 7.2 (3.3–15.7) | 0.5 (0.3–0.8) |
  ≥ 6 | 5 | 2 | 25.0 (8.7–49.1) | 98.1 (93.3–99.8) | 71.4 (29.0–96.3) | 87.3 (79.9–92.7) | 13.1 (2.7–63.0) | 0.8 (0.6–1.0) |